TITLE

Ineffective motility is not a marker for gastroesophageal reflux disease

AUTHOR(S)
Vinjirayer, Elango; Gonzalez, Begona; Brensinger, Colleen; Bracy, Nicole; Obelmejias, Robin; Katzka, David A.; Metz, David C.
PUB. DATE
April 2003
SOURCE
American Journal of Gastroenterology;Apr2003, Vol. 98 Issue 4, p771
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
: ObjectivePrevious studies have suggested that ineffective esophageal motility (IEM) may be a marker for gastroesophageal reflux disease (GERD), particularly supraesophageal reflux disease. We evaluated the relationship between esophageal acid exposure and esophageal body motility in patients undergoing both esophageal manometry and 24-h pH metry in the absence of antisecretory therapy.: MethodsWe conducted a retrospective database review of 84 patients (mean age 47 yr, 46% male) evaluated in our GI physiology laboratory. The indication for testing was recorded and characterized as esophageal or supraesophageal. Abnormal esophageal acid exposure was defined as a distal esophageal pH <4 for more than 4.2% of the total monitoring time (>6.3% upright, >1.2% supine) or a proximal esophageal acid exposure time of greater than 1.1% total (>1.3% upright, 0% supine). IEM was defined as more than two of 10 ineffective peristaltic waves.: ResultsSeventy-two patients had esophageal-presenting symptoms, and 12 had supraesophageal symptoms. The prevalence of abnormal esophageal acid exposure was similar in patients with esophageal and supraesophageal symptoms (69% vs 92%, p = 0.17). Abnormal motility was identified in 26 patients (31%). IEM was the most common motility disturbance (77%, 20 patients). The frequency of motility disorders was similar in patients with and without abnormal esophageal acid exposure (30% vs 35%, p = 0.79), in patients with esophageal or supraesophageal symptoms (32% vs 25%, p = 0.75, for all patients; 30% vs 27%, p = 1.00, for patients with abnormal esophageal acid exposure), and among upright, supine, and combined refluxers (33%, 9%, and 35%, p = 0.26).: ConclusionsIEM does not stand alone as a significant marker for the presence of GERD in general or supraesophageal reflux disease in particular.
ACCESSION #
9658090

 

Related Articles

  • Gastroesophageal reflux induced by white wine: the role of acid clearance and “rereflux”. Pehl, Christian; Frommherz, Martina; Wendl, Barbara; Pfeiffer, Albrecht // American Journal of Gastroenterology;Mar2002, Vol. 97 Issue 3, p561 

    OBJECTIVES:White wine has been demonstrated to induce gastroesophageal reflux (GER) in healthy people and GER patients. This GER is characterized by reflux episodes of prolonged duration. Our aim was to explore the pathogenesis of the prolonged reflux duration.METHODS:Twelve healthy volunteers...

  • Heartburn Is More Likely to Recur after Toupet Fundoplication than Nissen Fundoplication. Farrell, Timothy M.; Archer, Stephen B.; Galloway, Kathy D.; Branum, Gene D.; Smith, C. Daniel; Hunter, John G. // American Surgeon;Mar2000, Vol. 66 Issue 3, p229 

    Toupet (270 Degrees) fundoplication is commonly recommended for patients with gastroesophageal reflux (GER) and esophageal dysmotility. However, Toupet fundoplication may be less effective at protecting against reflux than Nissen (360 Degrees) fundoplication. We therefore compared the...

  • Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes. Shafik, Ahmed; El-Sibai, Olfat; Shafik, Ismail; Shafik, Ali // BMC Surgery;2004, Vol. 4, p13 

    Background: In view of the disturbed esophageal peristaltic activity and abnormal esophageal motility in gastroesophageal reflux disease, (GERD), we investigated the hypothesis that these changes result from a disordered myoelectric activity of the esophagus. Methods: The electric activity of...

  • Esophageal motility testing in the pre-op reflux evaluation. DeVault, Kenneth R; Achem, Sami R; Hinder, Ronald A // American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS12 

    An abstract of the article "Esophageal Motility Testing in the Pre-Op Reflux Evaluation," by Kenneth R. DeVault, Sami R. Achem and Ronald A. Hinder is presented.

  • Hyperdynamic Upper Esophageal Sphincter Pressure: A Manometric Observation in Patients Reporting Globus Sensation. Kwiatek, Monika A; Mirza, Faiz; Kahrilas, Peter J; Pandolfino, John E // American Journal of Gastroenterology;Feb2009, Vol. 104 Issue 2, p289 

    OBJECTIVES:Although globus sensation is a common symptom, its pathogenesis is poorly defined. The aim of this study was to quantify the timing and magnitude of respiratory variation in upper esophageal sphincter (UES) pressure with high-resolution manometry (HRM) in patients with globus...

  • Nonobstructive Dysphagia in Reflux Esophagitis. Triadafilopoulos, George // American Journal of Gastroenterology;Jun1989, Vol. 84 Issue 6, p614 

    Dysphagia in the absence of organic esophageal stricture may occur in patients with reflux esophagitis. Although the exact mechanism of this "nonobstructive dysphagia" (NOD) is not known, it is believed to be related to transient segmental esophageal motor disorder. The goals of this study were...

  • Is Barrett's Esophagus Characterized by More Pronounced Acid Reflux Than Severe Esophagitis? Coenraad, M.; Masclee, A. A. M.; Straathof, J. W. A.; Ganesh, S.; Griffioen, G.; Lamers, C. B. H. W. // American Journal of Gastroenterology;Jul1998, Vol. 93 Issue 7, p10668 

    Objective: Barrett's esophagus is related to gastroesophageal reflux disease (GERD). However, only a small fraction of patients with GERD develop Barrett's esophagus. We evaluated whether gastroesophageal acid reflux is more pronounced in Barrett's patients than in patients with moderate or...

  • Phlegmonous Esophagitis Associated with Epiphrenic Diverticulum. Mann, N. S.; Borkar, B. B.; Mann, S. K. // American Journal of Gastroenterology;Nov1978, Vol. 70 Issue 5, p510 

    Focuses on a case of phlegmonous esophagitis associated with epiphrenic diverticulum. Details of the case report; Esophageal motor abnormalities that are associated with a diverticula that can retain barium and food for long periods; Complaints of patients with large diverticula; Possible...

  • Abnormal acid reflux in asthmatic patients in a region with low GERD prevalence. Hsu, Jen-Yuan; Lien, Han-Chung; Chang, Chi-Sen; Chen, Gran-Hum // Journal of Gastroenterology;2005, Vol. 40 Issue 1, p11 

    Background. A high prevalence of gastroesophageal reflux disease (GERI)) in asthmatic patients has been reported from North America and Europe. However, only a few data from Asia are available. This study evaluated the incidence of abnormal gastroesophageal reflux (GER) in asthmatic patients in...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics