Lack of Association between ESR1 and CYP1A1 Gene Polymorphisms and Susceptibility to Uterine Leiomyoma in Female Patients of Iranian Descent

Mortezaee, Fatemeh Taghizade; Tabatabaiefar, Mohammad Amin; Chaleshtori, Morteza Hashemzadeh; Miraj, Sepideh
June 2014
Cell Journal (Yakhteh);Summer2014, Vol. 16 Issue 2, p225
Academic Journal
Uterine leiomyoma (UL) is the most common benign smooth muscle cell tumor with as yet unknown etiology and pathogenesis. This study was carried out to investigate the association of ESR1-351 A>G, ESR1 -397 T>C and CYP1A1 (Ile462Val) polymorphisms with UL in female patients of Iranian origin. In this case-control study, 276 patients with UL and 156 healthy women were recruited. The genetic polymorphisms ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (Ile462Val) were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). No significant difference were found in frequencies of both genotypes and alleles of ESR1-351 A>G, ESR1-397 T>C and CYP1A1 (Ile462Val) polymorphisms between the two groups (p>0.05). Our findings indicated that these ESR1 and CYP1A1 polymorphisms were not associated with the development of UL in the cases reported here.


Related Articles

  • Polymorphims in Interleukin 1-β Gene Increases Susceptibility.  // Fertility Weekly;12/14/2009, p6 

    The article examines the relation of polymorphisms in the interleukin-1β (IL-1β)-511 gene to uterine leiomyoma. Participants of this study were 131 women with leiomyoma and 280 women serving as controls. It was found that the polymorphism is related to an increased susceptibility to...

  • Estrogen receptors and human disease: an update. Burns, Katherine; Korach, Kenneth // Archives of Toxicology;Oct2012, Vol. 86 Issue 10, p1491 

    A myriad of physiological processes in mammals are influenced by estrogens and the estrogen receptors (ERs), ERα and ERβ. As we reviewed previously, given the widespread role for estrogen in normal human physiology, it is not surprising that estrogen is implicated in the development or...

  • No Association Between Estrogen Receptor Beta Polymorphisms and Uterine Leiomyoma. Zhai, Xian-Dun; Ye, Yi; Yang, Yang; Wang, Zheng; Mo, Yao-Nan // DNA & Cell Biology;Dec2009, Vol. 28 Issue 12, p633 

    Numerous candidate genes have been proposed as susceptibility factors for the development of uterine leiomyoma. Interaction of estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) plays a pivotal role in tunica muscularis uteri cell proliferation, differentiation, and tumorigenesis...

  • LIGNANS.  // American Herb Association Quarterly Newsletter;Autumn2007, Vol. 22 Issue 4, p13 

    The article features the lignan which are alter ego estrogen receptors and associated with a decreased risk of heart disease and hormonally related cancers. It is reported that 170 women with uterine fibroids when their diet was high in lignans. Eating lignans daily (10-30 miligrams) can provide...

  • Influence of Exogenous Estrogen Receptor Ligands on Uterine Leiomyoma: Evidence from an in Vitrol in Vivo Animal Model for Uterine Fibroids. Hunter, Deborah S.; Hodges, Leslie C.; Eagon, Patricia K.; Vonier, Peter M.; Fuchs-Young, Robin; Bergerson,, Jill S.; Walker, Cheryl L. // Environmental Health Perspectives Supplements;Oct2000 Supplement 5, Vol. 108, p829 

    Features investigations using the Eker rat model which show that uterine leiomyoma may have an enhanced sensitivity to modulation via the estrogen receptor. Hormonal modulation of uterine smooth muscle tissue; Effects of exogenous estrogen receptor ligands on uterine leiomyoma; Identifying...

  • Your doctor is in. Manson, Joan E. // Glamour;Sep2002, Vol. 100 Issue 9, p124 

    Provides information on uterine fibroids. Signs & symptoms of the disease in women; Diagnostic procedures for the condition; Medical treatment.

  • Uterine fibroids. Dhami, Sangeeta // GP: General Practitioner;6/17/2002, p76 

    Presents facts about uterine fibroids. Percentage of women affected by the condition; Classification of the fibroids; Clinical features of the disease.

  • Allergy and Uterine Leiomyomas: Cooperative Interaction with ACP1 Genetic Polymorphism. Gloria-Bottini, Fulvia; Ammendola, Maria; Saccucci, Patrizia; Pietropolli, Adalgisa; Neri, Anna; Magrini, Andrea; Bottini, Egidio // Journal of Reproduction & Infertility;Oct-Dec2015, Vol. 16 Issue 4, p199 

    Background: The possible association between allergy and neoplastic disorders has been the subject of many investigations but no general relationship has been determined. Little attention, however, has been paid to the possible role of allergy in the clinical manifestations of these diseases. In...

  • Long‐term effectiveness and safety of GnRH agonist plus raloxifene administration in women with uterine leiomyomas. Stefano Palomba; Francesco Orio; Tiziana Russo; Angela Falbo; Teresa Cascella; Patrizia Doldo; Carmine Nappi; Gaetano Lombardi; Pasquale Mastrantonio; Fulvio Zullo // Human Reproduction;June,2004, Vol. 19 Issue 6, p1308 

    BACKGROUND: Our aim was to evaluate the long‐term effectiveness and safety of GnRH agonist plus raloxifene administration in women with symptomatic uterine leiomyomas. METHODS: Fifty pre‐menopausal women with uterine leiomyomas were treated with leuprolide acetate depot at dose of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics