TITLE

Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria

AUTHOR(S)
Band, Victor I.; Ibegbu, Chris; Kaur, Surinder Pal; Cagle, Stephanie M.; Trible, Ronald; Jones, Crystal L.; Wang, Yun F.; Kraft, Colleen S.; Ray, Susan M.; Wrammert, Jens; Weiss, David S.
PUB. DATE
July 2014
SOURCE
Journal of Antimicrobial Chemotherapy (JAC);Jul2014, Vol. 69 Issue 7, p1830
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives Nosocomial pathogens such as Acinetobacter baumannii are a growing public health threat, due in part to their increasing resistance to antibiotics. Since some strains are resistant to all available antibiotics, novel therapies are urgently needed. Plasmablasts are short-lived B cells found in the blood that can be collected and harnessed to produce therapeutic antibodies. We set out to determine whether plasmablasts are induced during infection with A. baumannii and other nosocomial pathogens. Methods We obtained blood samples from patients infected with antibiotic-resistant nosocomial pathogens, and analysed their plasmablast response by flow cytometry. Results We observed a strong induction of plasmablasts in patients with antibiotic-resistant A. baumannii infection. Furthermore, plasmablasts were also induced in response to other drug-resistant nosocomial pathogens. Conclusions These data suggest that plasmablasts may be broadly harnessed to develop therapeutic antibodies to combat otherwise untreatable antibiotic-resistant infections.
ACCESSION #
96557012

 

Related Articles

  • Dutch Guideline for Preventing Nosocomial Transmission of Highly Resistant Microorganisms (HRMO). Kluytmans-VandenBergh, M. F. O.; Kluytmans, J. A. J. W.; Voss, A. // Infection;Oct2005, Vol. 33 Issue 5/6, p309 

    Hospitals are faced with the increasingly rapid emergence and dissemination of antimicrobial–resistant microorganisms. US and European guidelines on the prevention of antimicrobial resistance in hospitals were, until recently, mainly directed at methicillin–resistant Staphylococcus...

  • Healthcare-associated infections: Your role in prevention. Creech, Buddy; Schaffner, William; Talbot, Thomas R. // Patient Care for the Nurse Practitioner;Jun2007, Vol. 10 Issue 6, p6 

    The article discusses effective and practical ways to reduce healthcare-associated infection (HAI) in hospitals. Antibiotics should be prescribed only when necessary to avoid antibiotic resistance among hospital pathogens. Choose hospitals that have special infection control departments that...

  • Susceptibility patterns and cross resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital of Turkey. Gençer, Serap; Ak, Öznur; Benzonana, Nur; Ayşe Bat rel; Özer, Serdar // Annals of Clinical Microbiology & Antimicrobials;2002, Vol. 1, p1 

    Background: Pseudomonas aeruginosa is the third most common pathogen responsible for nosocomial infections and the prevalence of multiple resistant isolates has been increasing. Ninetynine clinical isolates were studied in order to assess the current levels of susceptibility and crossresistances...

  • Invasive device-associated nosocomial infections of a teaching hospital in Turkey; four years' experience. CANDEVİR, Aslıhan; KURTARAN, Behice; KİBAR, Filiz; KARAKOÇ, Emre; AKSU, Hasan Salih Zeki; TAŞOVA, Yeşim // Turkish Journal of Medical Sciences;Feb2011, Vol. 41 Issue 1, p137 

    No abstract available.

  • Quantifying changes in incidences of nosocomial bacteraemia caused by antibiotic-susceptible and antibiotic-resistant pathogens. Ammerlaan, Heidi S. M.; Troelstra, Annet; Kruitwagen, Cas L. J. J.; Kluytmans, Jan A. J. W.; Bonten, Marc J. M. // Journal of Antimicrobial Chemotherapy (JAC);May2009, Vol. 63 Issue 5, p1064 

    : Objectives The aim of this study was to determine, over time, changes in annual trends of nosocomial bacteraemia (NB) and to quantify pathogen-specific changes and emergence of antibiotic resistance. : Methods A retrospective cohort study in a 997 bed tertiary care centre in the Netherlands...

  • Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii. Chopra, Sidharth; Torres-Ortiz, Maria; Hokama, Leslie; Madrid, Peter; Tanga, Mary; Mortelmans, Kristien; Kodukula, Krishna; Galande, Amit K. // Journal of Antimicrobial Chemotherapy (JAC);Dec2010, Vol. 65 Issue 12, p2598 

    Objective The rising occurrence of drug-resistant pathogens accentuates the need to identify novel antibiotics. We wanted to identify new scaffolds for drug discovery by repurposing FDA-approved drugs against Acinetobacter baumannii, an emerging Gram-negative nosocomial drug-resistant pathogen....

  • Drug-Resistant Bacteria. Hawkins, James A. // Physician Executive;Nov/Dec2002, Vol. 28 Issue 6, p7 

    Reports on the increase in the number of drug-resistant bacteria in the U.S. Effect of antibiotic overuse and misuse on the growth of bacteria; Percentage of infections caused by Staphylococcus aureus; Status of drug-resistant bacteria prevalence in hospitals.

  • Antibiotic Resistance. Ambile-Cuevas, Carlos F.; Cardenas-Garcia, Maura; Ludgar, Mauricio // American Scientist;Jul/Aug95, Vol. 83 Issue 4, p320 

    Discusses the proliferation of bacteria which are resistant to antibiotics. Reasons behind antibiotic resistance; Role of nosocomial infections in the spread of resistant bacteria; Information on the method of resistance in bacteria; History of antibiotics; Details on the misuse of antibiotics.

  • Community-Associated MRSA – Resistance and Virulence Converge. Chambers, Henry F. // New England Journal of Medicine;4/7/2005, Vol. 352 Issue 14, p1485 

    The article presents information on Staphylococcus aureus as an important cause of disease and on antibiotic-resistant strains, which pose a threat to the community. Methicillin-resistant strains of Staphylococcus aureus (MRSA), were identified almost immediately and are now found in hospitals...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics