TITLE

Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice

AUTHOR(S)
Aytekin, Metin; Tonelli, Adriano R.; Farver, Carol F.; Feldstein, Ariel E.; Dweik, Raed A.
PUB. DATE
May 2014
SOURCE
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 5, p1935
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
96450902

 

Related Articles

  • Chronic thrombotic obstruction of major pulmonary arteries. Results of thromboendarterectomy in 15 patients. Moser, Kenneth M.; Spragg, Roger G.; Utley, Joseph; Daily, Pat O.; Moser, K M; Spragg, R G; Utley, J; Daily, P O // Annals of Internal Medicine;Sep83, Vol. 99 Issue 3, p299 

    Since 1969, 15 patients, ranging in age from 21 to 67 years, with pulmonary hypertension associated with chronic thrombotic obstruction of major pulmonary arteries have had pulmonary thromboendarterectomy. Symptoms compatible with embolism antedated surgery for periods of 8 months to 18 years;...

  • Idiopathic pulmonary arterial hypertension in a patient with pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis. Bachmeyer, C.; Khalil, A.; Kerrou, K.; Girot, R.; Gounant, V. // Annals of Hematology;Jun2009, Vol. 88 Issue 6, p603 

    A letter to the editor is presented on pulmonary arterial hypertension (PAH) in a patient having pyruvate kinase deficiency and paravertebral extramedullary hematopoiesis.

  • Current Treatment of the Pulmonary Arterial Hypertension. Gallego-Page, Juan C. // Current Respiratory Medicine Reviews;2007, Vol. 3 Issue 2, p129 

    Pulmonary arterial hypertension is a feature of a spectrum of diseases that includes elevated pulmonary vascular resistance, induces right ventricular insufficiency and heart failure, and threatens the life. The aetiology and pathogenesis is diverse and associated with elevated morbidity and...

  • Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension and Increased Pulmonary Vascular Remodeling in Mice. M. H. Xu; Gong, Y. S.; Su, M. S.; Dai, Z. Y.; Dai, S. S.; Bao, S. Z.; Li, N.; Zheng, R. Y.; He, J. C.; Chen, J. F.; Wang, X. T. // Journal of Vascular Research;2011, Vol. 48 Issue 2, p171 

    Background: Pulmonary arterial hypertension (PAH) is characterized by sustained elevation of pulmonary vascular resistance resulting from endothelial and smooth muscle cell dysfunction and collagen deposition in pulmonary vascular walls. In this study, we investigated the role of the adenosine...

  • Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity. Rahmouni, Kamal // Current Hypertension Reviews;May2010, Vol. 6 Issue 2, p104 

    Obesity increases cardiovascular morbidity and mortality in part by inducing hypertension. One factor linking excess fat mass to cardiovascular diseases may be the sympathetic cardiovascular actions of leptin. Initial studies of leptin showed it regulates appetite and enhances energy expenditure...

  • S-nitrosothiols signal hypoxia-mimetic vascular pathology. Palmer, Lisa A.; Doctor, Allan; Chhabra, Preeti; Sheram, Mary Lynn; Laubach, Victor E.; Karlinsey, Molly Z.; Forbes, Michael S.; MacDonald, Timothy; Gaston, Benjamin // Journal of Clinical Investigation;Sep2007, Vol. 117 Issue 9, p2592 

    NO transfer reactions between protein and peptide cysteines have been proposed to represent regulated signaling processes. We used the pharmaceutical antioxidant N-acetylcysteine (NAC) as a bait reactant to measure NO transfer reactions in blood and to study the vascular effects of these...

  • Editor's Memo. Burger, Charles // Advances in Pulmonary Hypertension;2016, Vol. 15 Issue 2, p58 

    The article discusses pediatric pulmonary arterial hypertension.

  • Natco Pharma submits ANDA for Bosentan Tablets for US market.  // Ace Analyser: Company News;6/6/2019, pN.PAG 

    Tracleer is indicated for the treatment of pulmonary arterial hypertension

  • Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin. Gomart, Samantha; Damoiseaux, Cécile; Jespers, Pascale; Makanga, Martine; Labranche, Nathalie; Pochet, Stéphanie; Michaux, Charles; Berkenboom, Guy; Naeije, Robert; McEntee, Kathleen; Dewachter, Laurence // Respiratory Research;2014, Vol. 15 Issue 2, p1 

    Background: Systemic hypertension may be associated with an increased pulmonary vascular resistance, which we hypothesized could be, at least in part, mediated by increased leptin. Methods: Vascular reactivity to phenylephrine (1 μmol/L), endothelin-1 (10 nmol/L) and leptin (0.001-100 nmol/L)...

  • Neonatal Pulmonary Artery Thrombosis Presenting as Persistent Pulmonary Hypertension of the Newborn. Sawyer, Taylor; Antle, Amanda; Studer, Matthew; Thompson, Mark; Perry, Stanton; Mahnke, C. Becket // Pediatric Cardiology;May2009, Vol. 30 Issue 4, p520 

    Pulmonary artery thrombosis in neonates occurs rarely. This report describes the case of a term infant with a pulmonary artery thrombosis presenting as persistent pulmonary hypertension of the newborn. The risk factors identified in the case included maternal diabetes and heterozygous factor V...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics