Overexpression of IL-9 induced by STAT6 activation promotes the pathogenesis of chronic lymphocytic leukemia

Na Chen; Kang Lu; Peipei Li; Xiao Lv; Xin Wang
May 2014
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 5, p2319
Academic Journal
No abstract available.


Related Articles

  • Stat3 Activates the Receptor Tyrosine Kinase Like Orphan Receptor-1 Gene in Chronic Lymphocytic Leukemia Cells. Ping Li; Harris, David; Zhiming Liu; Jie Liu; Keating, Michael; Estrov, Zeev // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: The receptor tyrosine kinase like orphan receptor (ROR)-1 gene is overexpressed in chronic lymphocytic leukemia (CLL). Because Stat3 is constitutively activated in CLL and sequence analysis revealed that the ROR1 promoter harbors γ-interferon activation sequence-like elements...

  • Signal Transducer and Activator of Transcription–3 Induces MicroRNA-155 Expression in Chronic Lymphocytic Leukemia. Li, Ping; Grgurevic, Srdana; Liu, Zhiming; Harris, David; Rozovski, Uri; Calin, George A.; Keating, Michael J.; Estrov, Zeev // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    MicroRNA (miR) abnormalities play a key role in the pathogenesis of chronic lymphocytic leukemia (CLL). High levels of miR-155 have been detected in human neoplasms, and overexpression of miR-155 has been found to induce lymphoma in mice. High levels of miR-155 were detected in CLL cells and...

  • IL-1β and TNFα-initiated IL-6–STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Mori, Tomoaki; Miyamoto, Takeshi; Yoshida, Hideyuki; Asakawa, Mayoko; Kawasumi, Miyuri; Kobayashi, Takashi; Morioka, Hideo; Chiba, Kazuhiro; Toyama, Yoshiaki; Yoshimura, Akihiko // International Immunology;Nov2011, Vol. 23 Issue 11, p701 

    Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint damage and significant disability. However, the fundamental mechanisms underlying how inflammation and joint destruction in RA develop and are sustained chronically remain largely unknown. Here, we show...

  • Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells Zhang, Guitao; Tsang, Chi Man; Deng, Wen; Yip, Yim Ling; Lui, Vivian Wai-Yan; Wong, Sze Chuen Cesar; Cheung, Annie Lai-Man; Hau, Pok Man; Zeng, Musheng; Lung, Maria Li; Chen, Honglin; Lo, Kwok Wai; Takada, Kenzo; Tsao, Sai Wah // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    Nasopharyngeal carcinoma (NPC) is etiologically associated with Epstein-Barr virus (EBV) infection. However, the exact role of EBV in NPC pathogenesis remains elusive. Activation of signal transducer and activator of transcription 3 (STAT3) is common in human cancers including NPC and plays an...

  • STAT1 is involved in the pathogenesis of murine allergic rhinitis. Hattori, Hisashi; Rosas, Lucia E.; Okano, Mitsuhiro; Durbin, Joan E.; Nishizaki, Kazunori; Satoskar, Abhay R. // American Journal of Rhinology;Mar/Apr2007, Vol. 21 Issue 2, p241 

    Background: Signal transducer and activator of transcription (STAT) 1 signaling pathway mediates biological functions of interferon (IFN) γ, which is a key cytokine-regulating T helper 1 (Th1) differentiation. Although constitutive activation of STAT1 has been reported in the airway...

  • Malignant Cutaneous T-Cell Lymphoma Cells Express IL-17 Utilizing the Jak3/Stat3 Signaling Pathway. Krejsgaard, Thorbjørn; Ralfkiaer, Ulrik; Clasen-Linde, Erik; Eriksen, Karsten W.; Kopp, Katharina L.; Bonefeld, Charlotte M.; Geisler, Carsten; Dabelsteen, Sally; Wasik, Mariusz A.; Ralfkiaer, Elisabeth; Woetmann, Anders; Odum, Niels // Journal of Investigative Dermatology;Jun2011, Vol. 131 Issue 6, p1331 

    IL-17 is a proinflammatory cytokine that is crucial for the host's protection against a range of extracellular pathogens. However, inappropriately regulated expression of IL-17 is associated with the development of inflammatory diseases and cancer. In cutaneous T-cell lymphoma (CTCL), malignant...

  • Physical and functional interactions between Daxx and STAT3. Muromoto, R.; Nakao, K.; Watanabe, T.; Sato, N.; Sekine, Y.; Sugiyama, K.; Oritani, K.; Shimoda, K.; Matsuda, T. // Oncogene;3/30/2006, Vol. 25 Issue 14, p2131 

    Signal transducer and activator of transcription 3 (STAT3) play key roles in the intracellular signaling pathways of the interleukin (IL)-6 family of cytokines, which exhibit a diverse set of cellular responses, including cell proliferation and differentiation. Dysregulated IL-6/STAT3 signaling...

  • Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27. Mingli Xu; Mizoguchi, Izuru; Morishima, Noriko; Chiba, Yukino; Mizuguchi, Junichiro; Yoshimoto, Takayuki // Clinical & Developmental Immunology;2010, p1 

    The interleukin (IL)-12 family, which is composed of heterodimeric cytokines including IL-12, IL-23, and IL-27, is produced by antigen-presenting cells such as macrophages and dendritic cells and plays critical roles in the regulation of helper T (Th) cell differentiation. IL-12 induces IFN-γ...

  • Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. Contri, Antonella; Brunati, Anna Maria; Trentin, Livio; Cabrelle, Anna; Miorin, Marta; Cesaro, Luca; Pinna, Lorenzo A.; Zambello, Renato; Semenzato, Gianpietro; Donella-Deana, Arianna // Journal of Clinical Investigation;Feb2005, Vol. 115 Issue 2, p369 

    B cell chronic lymphocytic leukemia (B-CLL) is a neoplastic disorder characterized by accumulation of B lymphocytes due to uncontrolled growth and resistance to apoptosis. Analysis of B cells freshly isolated from 40 patients with chronic lymphocytic leukemia demonstrated that the Src kinase...

  • Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma. Blix, Egil S.; Irish, Jonathan M.; Husebekk, Anne; Delabie, Jan; Forfang, Lise; Tierens, Anne M.; Myklebust, June H.; Kolstad, Arne // BMC Cancer;2012, Vol. 12 Issue 1, p478 

    Background: Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy. B-cell receptor (BCR) and co-receptor CD40 signaling is essential for normal B cells, and there is increasing...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics