DCC is expressed in a CD166-positive subpopulation of chondrocytes in human osteoarthritic cartilage and modulates CRE activity

Bosserhoff, Anja-Katrin; Hofmeister, Simone; Ruedel, Anke; Schubert, Thomas
May 2014
International Journal of Clinical & Experimental Pathology;2014, Vol. 7 Issue 5, p1947
Academic Journal
No abstract available.


Related Articles

  • IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation. Olivotto, Eleonora; Otero, Miguel; Astolfi, Annalisa; Platano, Daniela; Facchini, Annalisa; Pagani, Stefania; Flamigni, Flavio; Facchini, Andrea; Goldring, Mary B.; Borzì, Rosa Maria; Marcu, Kenneth B. // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Background: The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti- inflammatory responses, cellular survival and cellular differentiation. Here, we have investigated the mechanism of action...

  • The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. Lechler, Philipp; Balakrishnan, Sanjeevi; Schaumburger, Jens; Grässel, Susanne; Baier, Clemens; Grifka, Joachim; Straub, Rainer H.; Renkawitz, Tobias // BMC Musculoskeletal Disorders;2011, Vol. 12 Issue 1, p150 

    Background: Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis and maintenance of cell viability during embryonic development and in...

  • Identification of a central role for complement in osteoarthritis. Wang, Qian; Rozelle, Andrew L; Lepus, Christin M; Scanzello, Carla R; Song, Jason J; Larsen, D Meegan; Crish, James F; Bebek, Gurkan; Ritter, Susan Y; Lindstrom, Tamsin M; Hwang, Inyong; Wong, Heidi H; Punzi, Leonardo; Encarnacion, Angelo; Shamloo, Mehrdad; Goodman, Stuart B; Wyss-Coray, Tony; Goldring, Steven R; Banda, Nirmal K; Thurman, Joshua M // Nature Medicine;Dec2011, Vol. 17 Issue 12, p1674 

    Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has long been viewed as the result of 'wear and tear'. Although low-grade inflammation is detected in osteoarthritis, its role is unclear. Here we identify a central role for the inflammatory complement...

  • Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone. Pullig, O.; Weseloh, G.; Ronneberger, D.-L.; Käkönen, S.-M.; Swoboda, B.; Ronneberger, D; Käkönen, S // Calcified Tissue International;Sep2000, Vol. 67 Issue 3, p230 

    Osteocalcin (OC), which is a marker of the mature osteoblasts, can also be found in posthypertrophic chondrocytes of the epiphyseal growth plate, but not in chondrocytes of the resting zone or in adult cartilage. In human osteoarthritis (OA), chondrocytes can differentiate to a hypertrophic...

  • Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction. Siyoung Yang; Jonghwan Kim; Je-Hwang Ryu; Hwanhee Oh; Churl-Hong Chun; Byoung Ju Kim; Byoung Hyun Min; Jang-Soo Chun // Nature Medicine;Jun2010, Vol. 16 Issue 6, p687 

    Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by EPAS1) is a catabolic transcription factor in the osteoarthritic process. HIF-2α directly induces the expression in...

  • New Emerging Role of Pitx1 Transcription Factor in Osteoarthritis Pathogenesis. Cynthia Picard // Clinical Orthopaedics & Related Research;Sep2007, Vol. 462 Issue 1, p59 

    Osteoarthritis is the most common form of arthritis and the precise etiology of this disease remains unclear. We took a candidate gene-driven strategy approach based on the observation that Pitx1 transcription factor was found during hind limb development in regions giving rise to cartilage...

  • Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Lin, Alvin C.; Seeto, Brian L.; Bartoszko, Justyna M.; Khoury, Michael A.; Whetstone, Heather; Ho, Louisa; Hsu, Claire; Ali, Amanda S.; Alman, Benjamin A. // Nature Medicine;Dec2009, Vol. 15 Issue 12, p1421 

    Osteoarthritis is associated with the irreversible degeneration of articular cartilage. Notably, in this condition, articular cartilage chondrocytes undergo phenotypic and gene expression changes that are reminiscent of their end-stage differentiation in the growth plate during skeletal...

  • Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration. Schubert, Thomas; Kaufmann, Simone; Wenke, Ann-Kathrin; Grässel, Susanne; Bosserhoff, Anja-Katrin // Rheumatology;Nov2009, Vol. 48 Issue 11, p1435 

    Objective. The concept of the chondrocyte as a stationary cell surrounded by an apparently impenetrable matrix has been challenged by in vitro observations in recent years. Chondrocyte migration may have a role in remodelling of the cartilage and pathological conditions. Candidate molecules are...

  • Das 'onkofetale' Gen Survivin - ein mögliches Ziel-Gen regenerativer Therapiekonzepte im Gelenkknorpel. Lechler, P.; Handel, M.; Anders, S.; Balakrishnan, S.; Grifka, J. // Der Orthopäde;Apr2012, Vol. 41 Issue 4, p260 

    Survivin, the smallest member of the inhibitor of the apoptosis protein gene family (IAP) is a key molecule for mammalian cell cycle regulation and cellular survival. Of note these functions have been thought to be limited to embryonic and malignant tissues. However, a growing body of evidence...

  • Cytoskeletal architecture and cathepsin B trafficking in human articular chondrocytes. Zwicky, Roman; Baici, Antonio // Histochemistry & Cell Biology;Nov2000, Vol. 114 Issue 5, p363 

    In the differentiated state, human articular chondrocytes exhibited modestly developed cytoskeletal components, while cells dedifferentiated by serial subcultures in vitro displayed a prominent cytoskeleton. Morphological changes, a well-developed actin cytoskeleton, and the presence of numerous...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics