TITLE

Antidiabetic Mechanism of Standardized Extract, Fraction and Subfraction of Cinnamomum Iners Leaves

AUTHOR(S)
Mustaffa, Fazlina; Hassan, Zurina; Yusof, Nur Adlin; Abdul Razak, Khairul Niza; Asmawi, Mohd Zaini
PUB. DATE
May 2014
SOURCE
International Journal of Pharmaceutical Sciences Review & Resear;May/Jun2014, Vol. 26 Issue 2, p209
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Diabetes mellitus is predicted to become one of the world's main disablers and killers within the next 25 years. One of therapeutic approach for treating diabetes is to reduce postprandial hyperglycemia by inhibition of carbohydrate hydrolyzing enzymes such as a- glucosidase and a-amylase. The objective of the present manuscript is to screen the in vivo and in vitro inhibitory effect of active methanol extract, chloroform fraction and sub-fraction 1 of Cinnamomum iners leaves together with cinnamic aldehyde, a well known antidiabetic compound presence in the samples against a-glucosidase and a-amylase enzymes. In addition, ex vivo study for inhibition of glucose absorption from the intestine by methanol extract, chloroform fraction and sub-fraction 1 of C. iners leaves was assessed. The results indicate that sub-fraction 1 of C. iners leaves showed appreciable inhibition activity against a-glucosidase, a- amylase enzymes and reduce glucose absorption by intestine. It could be speculated that the antidiabetic mechanism of C. iners is by decreasing postprandial hyperglycemia, thus it is useful in management of type 2 insulin independent diabetes mellitus. Cinnamic aldehyde was identified as the major bioactive constituent presence in the sub-fraction 1.
ACCESSION #
96444004

 

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