TITLE

In vitro hemocompatibility evaluation of poly (4-hydroxybutyrate) scaffold

AUTHOR(S)
Yunqi Liu; Dongmei Cai; Jing Yang; Yujie Wang; Xi Zhang; Shengli Yin
PUB. DATE
June 2014
SOURCE
International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 5, p1233
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The biosynthetic thermoplastic poly-4-hydroxybutyrate (P4HB) possesses favorable tensile strength and elongation performance and has been studied as a new implantable polymer material for medical uses. However, its hemocompatibility has not been tested to confirm its applicability to tissue engineering. In this study, a series of experiments was performed that included erythrocyte hemolysis tests, dynamic blood coagulation tests, platelet adhesion tests, effects on blood coagulation, Wright staining, and adsorption of erythrocytes, leukocytes, platelets, and plasma proteins. The results were compared with control tests on polyvinyl chloride (PVC), a biomaterial in current use, to evaluate the relative in vitro hemocompatibility of P4HB. The degree of hemolysis in the presence of P4HB was 1.9 ± 0.2%. The absorbance-time curve for blood clotting declined slowly and smoothly. There were no differences in the test values of Factor XII, activated partial thromboplastin time (APTT), or fibrin degradation products (FDPs) among whole blood samples exposed to P4HB or PVC and the blank control groups (P > .05). Adsorption of platelets and globulin was similar in samples exposed to P4HB and PVC (P > .05), but the adsorption of erythrocytes, leukocytes, and albumin to P4HB was higher (P < .05). In conclusion, P4HB compares favorably with PVC in terms of blood compatibility, except for a higher affinity for erythrocytes and leukocytes. The findings indicate that P4HB, an alternate scaffolding material with advantageous properties, is generally acceptable for bioengineering use.
ACCESSION #
96422522

 

Related Articles

  • Investigation of Polyvinyl Chloride and Thermoplastic Polyurethane Waste Blend Miscibility. LAUKAITIENĖ, Agnė; JANKAUSKAITĖ, Virginija; ŽUKIENĖ, Kristina; NORVYDAS, Valdas; MUNASSIPOV, Serik; JANAKHMETOV, Urynbassar // Materials Science / Medziagotyra;2013, Vol. 19 Issue 4, p397 

    In this study the miscibility of polyvinyl chloride (PVC) and poly-e-caprolactone based thermoplastic polyurethanes (TPU) waste blends were investigated by dilute solution viscometry. The miscibility criteria a, Db, DB, and D[h] were used to assess the degree of miscibility of polymers in...

  • Ispitivanje mehaničkih osobina polivinil-hlorida sa dodatkom modifikovanog kalcita kao punioca. Mihajlović, Slavica R.; Sekulić, Živko T.; Vučinić, DuŠica R.; Jovanović, Vladimir D.; Kolonja, Božo M. // Chemical Industry / Hemijska Industrija;2012, Vol. 66 Issue 5, p787 

    In this study, mechanical properties of PVC mixtures (PVC, stabilizer, lubricant and filler) such as tensile strength, tensile elongation, breaking strength, and breaking elongation were investigated. Unmodified calcite, as well as calcite modified by stearic acid, were used as fillers in wet...

  • An influence of isocyanate structure of poly(urethane-urea) hard segments on the interfacial interactions with poly(vinyl chloride). Malysheva, T. L.; Golovan, S. V.; Klimchyk, D. A. // Polymer Journal (18181724);2012, Vol. 34 Issue 1, p29 

    An influence of isocyanate structure of poly(urethane-urea) hard segments on the interfacial interactions with poly(vinyl chloride), as well as structure and the physical-mechanical properties of blends has been studied. A compatibility and tensile strength of composites decrease in the range:...

  • The Effect of Triacetin on the Plasticization Efficiency and Tensile Properties of Polyvinyl Chloride/di-2-Ethyl Hexyl Phthalate/Triacetin Compounds. ARJULIZAN Rusli; NUR FARHANA Asul Kahar // Advanced Materials Research;2016, Vol. 1133, p206 

    The use of triacetin as an alternative plasticizer to polyvinyl chloride (PVC) was studied in terms of plasticizer efficiency and tensile properties before and after ageing. The efficiency of plasticizers was evaluated based on the glass transition temperature (Tg) and the hardness value of the...

  • Executive summary.  // Rubber & Plastics News;4/20/2015, Vol. 44 Issue 19, p0016 

    The article presents a study which explores the cost effectiveness of alternative plasticizers. It discusses various plasticizers substitutes such as extremely durable synthetic rubber (EPDM), nitrile rubber (NBR) / polyvinyl chloride (PVC), and chlorosulfonated polyethylene rubber (CSM). Also...

  • Proteomic analysis of calcium-enriched sol–gel biomaterials. Romero-Gavilán, F.; Araújo-Gomes, Nuno; Cerqueira, A.; García-Arnáez, I.; Martínez-Ramos, C.; Azkargorta, M.; Iloro, I.; Elortza, F.; Gurruchaga, M.; Suay, J.; Goñi, I. // Journal of Biological Inorganic Chemistry;Jun2019, Vol. 24 Issue 4, p563 

    Calcium is an element widely used in the development of biomaterials for bone tissue engineering as it plays important roles in bone metabolism and blood coagulation. The Ca ions can condition the microenvironment at the tissue–material interface, affecting the protein deposition process...

  • Effect of Gamma Radiation on the Properties of Poly(3-Hydroxybutyrate- co-3-Hydroxyvalerate)/Poly(ε-Caprolactone) Blends. Rosário, Francisco; Corradini, Elisângela; Casarin, Suzan; Agnelli, José // Journal of Polymers & the Environment;Sep2013, Vol. 21 Issue 3, p789 

    Poly(3-hydroxybutyrate- co-3-hydroxyvalerate) (PHBV) and poly(ε-caprolactone) (PCL) and a PHBV/PCL blend with a 75/25 composition (wt%) were processed by injection molding and then subjected to 50 and 100 kGy of gamma radiation. The crystallinity of pure PHBV and PCL and the PHBV/PCL blend...

  • Processing and Mechanical Properties of Natural Rubber/Chitosan/Poly(3-hydroxybutyrate) Blends. Guang Lu; Honghai Huang; Heping Yu; Yongzhou Wang // Advanced Materials Research;2014, Issue 1033-1034, p912 

    In an attempt to improve the properties of natural rubber-based medical products, natural rubber (NR) was blended with chitosan (CS) and poly(3-hydroxybutyrate) (PHB) in an laboratory type internal mixer, with the total amount of CS and PHB is of 1, 3, 5, 10, 15 and 20 parts per hundred rubber...

  • Preparation and characterization of biodegradable blends of poly(3-hydroxybutyrate-co-3- hydroxyhexanoate) and poly(butylene adipate-co-terephthalate). Min Zhang; Xiaoqian Diao; Yujuan Jin; Yunxuan Weng // Journal of Polymer Engineering;Jul2016, Vol. 36 Issue 5, p473 

    Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) was blended with poly(butylene adipate-co-terephthalate) (PBAT) by extrusion at different weight ratios (PHBH/PBAT: 100:0, 80:20, 60:40, 50:50, 40:60, 20:80 and 0:100). Films were then prepared from the blends and characterized in terms of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics