Nocardial brain abscess in an immunocompromised old patient: a case report and review of literature

Hailiang Tang; Tianming Mao; Ye Gong; Ying Mao; Qing Xie; Daijun Wang; Hongda Zhu; Xiancheng Chen; Liangfu Zhou
June 2014
International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 5, p1480
Academic Journal
Background: Nocardial brain abscess is a rare central nervous system (CNS) infection with high morbidity and mortality. The infection is acquired through inhalation or direct contact with the bacteria, and could spreads through blood transmission. Nocardial brain abscess is usually associated with immunocompromised patients, but sometimes may appear in healthy individuals. Treatment is based on stereotaxic aspiration or surgical resection, and antibiotics therapy for several months. Clinical presentation: We presented one case of nocardial brain abscess treated at our department with review the literature. The patient was 65-year-old with ANCA polyangitis. She had oral methylprednisolone tablets treatment for over 6 months. The patient was treated with surgical evacuation and long-term antibiotics. The patient recovered well at discharge. Conclusion: Nocardial brain abscess is a rare CNS infection that needs to be differentiated from other brain lesions. It could occur in immunocompromised patients or healthy individuals. Treatment includes surgical intervention and long-term antibiotics therapy.


Related Articles

  • Impact of round-the-clock CSF Gram stain on empirical therapy for suspected central nervous system infections. Tissot, F.; Prod'hom, G.; Manuel, O.; Greub, G. // European Journal of Clinical Microbiology & Infectious Diseases;Sep2015, Vol. 34 Issue 9, p1849 

    The impact of round-the-clock cerebrospinal fluid (CSF) Gram stain on overnight empirical therapy for suspected central nervous system (CNS) infections was investigated. All consecutive overnight CSF Gram stains between 2006 and 2011 were included. The impact of a positive or a negative test on...

  • Neurocysticercosis--More Than a Neglected Disease. Nash, Theodore E.; Mahanty, Siddhartha; Garcia, Hector H. // PLoS Neglected Tropical Diseases;Apr2013, Vol. 7 Issue 4, p1 

    The authors reflect on the management and control of neurocysticercosis (NCC). They discuss the development of drugs and intervention strategies for the disease and mention the introduction of oxfendazole. The article also notes the use of ventricular endoscopy as well as the anthelminthic...

  • Unterschiedliche Manifestationsformen der zerebralen Nokardiose. D. Buelte; J. Noth; M. Mull; B. Sellhaus; A. Koch; M. Queider; F. Hünger; R. Gobbelé // Der Nervenarzt;Dec2008, Vol. 79 Issue 12, p1432 

    Zusammenfassung  Nokardien verursachen häufig pulmonale Infektionen, können aber auch in seltenen Fällen zum Befall des zentralen Nervensystems (ZNS) führen. Zur Behandlung zerebraler Nokardiosen gibt es nur wenig klinische Erfahrungen. Wir möchten zwei Fälle mit...

  • The Emerging Therapeutic Role of RNA Interference in Disorders of the Central Nervous System. Dessy, A.; Gorman, J. M. // Clinical Pharmacology & Therapeutics;Mar2011, Vol. 89 Issue 3, p450 

    The article focuses on the application of RNA interference (RNAi) in treating disorders of the central nervous system (CNS) which include Huntington's disease, spinocerebellar ataxia, and Alzheimer's disease. It says that RNAi prevents translation by degradation or disabling messenger RNA (mRNA)...

  • Cysticidal Efficacy of Combined Treatment With Praziquantel and Albendazole for Parenchymal Brain Cysticercosis. Garcia, Hector H.; Lescano, Andres G.; Gonzales, Isidro; Bustos, Javier A.; Javier Pretell, E.; Horton, John; Saavedra, Herbert; Gonzalez, Armando E.; Gilman, Robert H. // Clinical Infectious Diseases;6/1/2016, Vol. 62 Issue 11, p1375 

    Background. The efficacy of current antiparasitic treatment for cerebral Taenia solium cysticercosis with either albendazole (ABZ) or praziquantel (PZQ) is suboptimal. A recent study demonstrated that combining these 2 antiparasitic drugs improves antiparasitic efficacy. We present here the...

  • Neurocysticercosis. Moskowitz, Jack; Mendelsohn, Geoffrey // Archives of Pathology & Laboratory Medicine;Oct2010, Vol. 134 Issue 10, p1560 

    Neurocysticercosis is a significant public health issue within the United States. Although cysticercosis was once thought to have been eradicated in the United States, the number of documented cases is rising and immigrants from endemic areas are at the highest risk for acquiring and developing...

  • Are the colors and shapes of current psychotropics designed to maximize the placebo response? Khan, Arif; Bomminayuni, Eswara Prasad; Bhat, Amritha; Faucett, James; Brown, Walter A. // Psychopharmacology;Aug2010, Vol. 211 Issue 1, p113 

    Patient expectations are an important aspect of the placebo response. Color and shape of a medication lead to perceptions that an agent is stimulating or calming, strong or weak. We assessed the degree to which central nervous system medications match the perceived drug action and thereby...

  • DO NOT CRUSH OR CHEW.  // Monthly Prescribing Reference;Jun2014, Vol. 30 Issue 6, p120 

    The article evaluates several drugs for the treatment of allergic disorders, central nervous system disorders and endocrine system disorders including Chlor-Trimeton, Ambien CR and Fortamet.

  • Tuberculosis Infections of the Central Nervous System. Bartzatt, Ronald // Central Nervous System Agents in Medicinal Chemistry;Dec2011, Vol. 11 Issue 4, p321 

    The causative agent of Tuberculosis meningitis is Mycobacterium tuberculosis, which is the bacteria that causes pulmonary tuberculosis. Proliferating into the central nervous system occurs from other sites of infection within the body. Brain damage can result from the infection that may lead to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics