TITLE

Overexpression of microRNA-21 and microRNA-126 in the patients of bronchial asthma

AUTHOR(S)
Xian-Bo Wu; Ming-Yi Wang; Hai-Yan Zhu; Song-Qi Tang; Yao-Dong You; Yi-Qiang Xie
PUB. DATE
June 2014
SOURCE
International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 5, p1307
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
MicroRNAs are implicated in an increasing number of diseases and health complications, including asthma. Previous studies have suggested roles for microRNA-21 (miR-21) and microRNA-126 (miR-126) in asthma, although these relationships are incompletely understood. The aim of this study was to further assess the relationship between miR-21, miR-126 and the occurrence and treatment of allergic asthma. Quantitative real-time PCR analyzed expression levels of miR-21 and miR-126 in bronchial epidermal cells from asthma patients treated with (treatment group, n=19) or without (non-treatment group, n=16) inhaled corticosteroids or from non-asthmatic healthy individuals (normal group, n=12). Bronchial epidermal cells were cultured in vitro to determine if there was a relationship between IL-13 and miR-21 and miR-126 expression. Compared to the normal group, miR-21 and miR-126 expression was significantly upregulated in asthma patients regardless of treatment. miR-21 and miR-126 expression was significantly higher in the non-treatment group than the treatment group (P<0.05). In vitro, miR-21 and miR-126 expression increased in bronchial epidermal cells with increasing IL-13 concentration. Because upregulation of miR-126 and miR-21 were associated with occurrence and therapy of allergic asthma, they may be indices of therapeutic effect that are valuable for the evaluation for asthma treatment.
ACCESSION #
96422498

 

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