TITLE

Uncommon Asymptomatic Plasmodium falciparum Infections in Gabonese Children

AUTHOR(S)
Missinou, Michel A.; Lell, Bertrand; Kremsner, Peter G.
PUB. DATE
May 2003
SOURCE
Clinical Infectious Diseases;5/1/2003, Vol. 36 Issue 9, p1198
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To assess the frequency of asymptomatic plasmodial infections in young children living in an area of hyperendemicity, a cohort of 200 children in Gabon was investigated longitudinally. Of 660 cases of Plasmodium falciparum infection, 77 4.992440e-305re symptomatic at the time they were identified and only 7 2.636851e-308re preceded by an asymptomatic phase of > 4 days. Sickle cell trait, glucose-6-phosphate dehydrogenase deficiency, and mutation in the promoter region of tumor necrosis factor (TNF[SUP-376A/-238A]) were significantly associated with asymptomatic P. falciparum infection (P = .03, P = .009, and P < .001, respectively). We conclude that true asymptomatic cases of P. falciparum infection are uncommon in young children and that single measurements or measurements made at long time intervals will lead to a strong underestimation of the incidence of malaria.
ACCESSION #
9632485

 

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