Relationship of Kaposi Sarcoma (KS)-Associated Herpesvirus Viremia and KS Disease in Zimbabwe

Ison, Michael G.; Hayden, Frederick G.; Kaiser, Laurent; Corey, Lawrence; Boeckh, Michael
May 2003
Clinical Infectious Diseases;5/1/2003, Vol. 36 Issue 9, p1144
Academic Journal
The relationship between Kaposi sarcoma--associated herpesvirus (KSHV) viremia and KS disease was investigated in 500 subjects who received treatment in Harare, Zimbabwe. Subjects were grouped by results of human immunodeficiency virus (HIV) type 1 serological tests, KS diagnosis, and KS clinical stage. The plasma KSHV DNA concentration was associated with concomitant KS and HIV-1 infection (AIDS-KS; P < .001) and AIDS-KS clinical stage (P = .01). Plasma KSHV DNA levels were greater in AIDS-KS than in matched HIV-1-seronegative KS (P = .04). The plasma KSHV DNA level was not associated with age, sex, systemic symptoms, or CD4[SUP+] lymphocyte count. Plasma and peripheral blood mononuclear cell KSHV DNA concentrations were linearly related (r[SUP2] = .44; P < .001), and the nucleotide sequence of the K1 gene highly variable region was identical in both compartments. These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection.


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