TITLE

Rhinovirus Infections in Hematopoietic Stem Cell Transplant Recipients with Pneumonia

AUTHOR(S)
Ison, Michael G.; Hayden, Frederick G.; Kaiser, Laurent; Corey, Lawrence; Boeckh, Michael
PUB. DATE
May 2003
SOURCE
Clinical Infectious Diseases;5/1/2003, Vol. 36 Issue 9, p1139
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Little is known about the impact of human rhinovirus (HRV) and coronavirus infections in hematopoietic stem cell transplant (HSCT) recipients. We tested bronchoalveolar lavage (BAL) samples obtained from HSCT recipients with acute pulmonary infiltrates for HRV (n = 122) and coronavirus (n = 46) by reverse-transcriptase polymerase chain reaction. HRV RNA was detected in 6 (8) of 77 patients, and coronavirus RNA was detected in 0 of 46 of BAL samples from HSCT recipients. The fatality rate in HRV-infected patients was high (83), but all patients had significant coinfections, and the overall mortality rate was not different from that of patients who were negative for HRV in BAL samples. These results suggest that HRV may be a cause of lower respiratory tract infections in HSCT recipients and that its detection in BAL samples is associated with frequent copathogens. Whether the poor prognosis is due to HRV or the copathogen is not clear.
ACCESSION #
9632458

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics