TITLE

Role of n-3 fatty acids in muscle loss and myosteatosis1

AUTHOR(S)
Ewaschuk, Julia B.; Almasud, Alaa; Mazurak, Vera C.
PUB. DATE
June 2014
SOURCE
Applied Physiology, Nutrition & Metabolism;Jun2014, Vol. 39 Issue 6, p654
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Image-based methods such as computed tomography for assessing body composition enables quantification of muscle mass and muscle density and reveals that low muscle mass and myosteatosis (fat infiltration into muscle) are common in people with cancer. Myosteatosis and low muscle mass have emerged as independent risk factors for mortality in cancer; however, the characteristics and pathogenesis of these features have not been resolved. Muscle depletion is associated with low plasma eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) in cancer and supplementation with n-3 fatty acids has been shown to ameliorate muscle loss and myosteatosis in clinical studies, suggesting a relationship between n-3 fatty acids and muscle health. Since the mechanisms by which n-3 fatty acids alter body composition in cancer remain unknown, related literature from other conditions associated with myosteatosis, such as insulin resistance and obesity is considered. In these noncancer conditions, it has been reported that n-3 fatty acids act by increasing insulin sensitivity, reducing inflammatory mediators, and altering adipokine profiles and transcription factors; therefore, the plausibility of these mechanisms of action in the neoplastic state are considered. The aim of this review is to summarize what is known about the effects of n-3 fatty acids with regards to muscle condition and to discuss potential mechanisms for effects of n-3 fatty acids on muscle health.
ACCESSION #
96226640

 

Related Articles

  • A Tide of Evidence Washes Away Flawed Fish Oil Prostate Cancer Study.  // Positive Health;Aug2013, Issue 208, p1 

    The article discusses the study led by Doctor Theodore Brasky of the Fred Hutchinson Cancer Research Center in Seattle, Washington on the link between fatty acids, including the long-chain omega-3 fatty acids, and cancer. Based on the National Cancer Institute, 125 male out of 100,000 could...

  • Effects of Pure Eicosapentaenoic and Docosahexaenoic Acids on Oxidative Stress, Inflammation and Body Fat Mass in Patients with Type 2 Diabetes. Soleiman, Fatemeh Azizi; Jazayeri, Shima; Eghtesadi, Shahryar; Rajab, Asadollah; Heidariz, Iraj; Vafa, Mohammad R.; Gohari, Mahmood R. // International Journal of Preventive Medicine;Aug2013, Vol. 4 Issue 8, p922 

    Background: N 3 Fatty acids reduce the risk of cardiovascular disease. Previous studies have shown that they may reduce inflammation, oxidative stress, and fat mass in patients with type 2 diabetes, but the results are inconclusive, due, in part, to type of omega 3 fatty acids used. The aim of...

  • Omega-3s mature NOW A $2 BILLION SEGMENT.  // Functional Ingredients;Oct2012, Issue 123, p20 

    An excerpt from the publication "NBJ/ENGREDEA Monograph: Ingredient Market Forecast" is presented.

  • The great dilemma.  // Choice;Nov2008, p22 

    The article investigates the benefits and risks of eating fish. Several health benefits from the omega-3 fatty acids, EPA and DHA found in fish include reduction of risk of heart disease and cognitive impairment. Some toxic chemicals that fish contain are mercury and dioxins. Meanwhile, Food...

  • Gone fishin'  // Functional Ingredients;Apr2013, Issue 127, p20 

    The article presents an interview with Steve Dillingham, the general manager of the fish oil supply company G. C. Rieber Oils, in which he discusses the regulation of omega-3 fatty acid supplements in the U.S., the marketing of omega-3 products and C. G. Rieber's marketing of omega-3 products. A...

  • THE ROLE OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS IN THE TREATMENT OF CANCER CACHEXIA AND TUMOUR GROWTH IN PATIENTS WITH MALIGNANT DISEASES: A REVIEW. Symington, Elizabeth A.; Gericke, Gerda J. // Health SA Gesondheid;Jun2008, Vol. 13 Issue 2, p49 

    Recent studies show that ω-3 polyunsaturated fatty acids (PUFAs) have the capacity to modulate cancer outcomes. The body responds to cancer in the same way that it responds to inflammation and wound healing. Nutrients with anti-inflammatory effects could therefore be expected to play a role...

  • Fatty acid composition in farmed great sturgeon Huso huso. Ghomi, Mohammad; Nikoo, Mehdi; Babaei, Zeinolabedin // Comparative Clinical Pathology;Feb2012, Vol. 21 Issue 1, p111 

    In this study, fatty acid profiles in farmed great sturgeon Huso huso were determined and results compared with those of other farmed sturgeon species. C18:1, C18:2, C16:0, C18:3, and C18:0 were the main fatty acids found in great sturgeon flesh and represented approximately 88% of total fatty...

  • Omega-3s: STARS OF THE INGREDIENT FIRMAMENT.  // Functional Ingredients;Mar2011, Issue 106, p22 

    The article presents an overview of the health benefits which are associated with consuming omega-3 fatty acids and discusses the sources from which they are derived. A discussion of the physiological effects and suggested dosages of the fatty acids, and of manufacturing constraints which are...

  • Farmed fish: a major provider or a major consumer of omega-3 oils?  // FAO Aquaculture Newsletter;Dec2012, Issue 50, p4 

    The article focuses on the health benefits offered by fish and any other seafood products, specifically from their omega-3 fatty acid content docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), as well as the significance of these acids in fish diet. It notes that DHA and EPA are imperative...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics