The reaction mechanism of the internal thioester in the human complement component C4

Dodds, Alister W.; Xiang-Dong Ren
January 1996
Nature;1/11/1996, Vol. 379 Issue 6561, p177
Academic Journal
Investigates the binding of the human C3A isotype which involves a direct reaction between amino-nucleophiles and the thioester. Covalent binding of complement proteins C3 and C4 to their surfaces as a key step in the elimination of pathogens from the body; Two-step mechanism used bye C3B istotype; Physiological effect of proteolytic activation of the proteins.


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