TITLE

Biopolymer matrix systems for incorporation of biologically active substances

AUTHOR(S)
Dyankova, S.; Solak, A.
PUB. DATE
March 2014
SOURCE
Agricultural Science & Technology (1313-8820);Mar2014, Vol. 6 Issue 1, p104
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A number of biopolymers have a potential to be used as a basis for producing films, coatings and therapeutic systems with application in medicine, pharmacy and food industry. The objective of the present work was to obtain monopolymer and composite matrices which can be used as carriers of biologically active substances. Protein (collagen, gelatin, soy protein) and polysaccharide (sodium alginate, highmethoxyl pectin, carrageenan and carboxymethylcellulose) hydrocolloids were investigated and a method for producing monopolymer and composite films was developed. The obtained materials were characterized by their physicochemical and mechanical properties; their behavior at different pH values and in media simulating the conditions in the gastrointestinal tract. The protein films showed lower moisture content and absorbed less water compared to the polysaccharide films. It was found that films prepared from collagen dispersions were the most resistant at different pH and in simulated gastric and intestinal juice. The polysaccharide films dissolved under the studied conditions except for the alginates which kept their wholeness in acidic medium and in simulated gastric juice, but degraded in intestinal juice. The combination of two biopolymers -- protein-polysaccharide or polysaccharide-polysaccharide improved considerably the mechanical properties of the films. All composite films also showed significant differences in the dissolution profile compared to the individual biopolymer films.
ACCESSION #
95984827

 

Related Articles

  • Factors Influencing the Formation and Stability of Filled Hydrogel Particles Fabricated by Protein/Polysaccharide Phase Separation and Enzymatic Cross-Linking. Matalanis, Alison; McClements, David // Food Biophysics;Mar2012, Vol. 7 Issue 1, p72 

    Filled hydrogel particles can be used to encapsulate, protect, and deliver lipophilic components. In this study, we investigated the influence of preparation conditions on the size of filled hydrogel particles created using biopolymer phase separation and enzymatic cross-linking. We then...

  • Study of Biopolymer Chitosan as Resist for Submicron Electronic Lithography. Voznesenskiy, S.; Nepomnyaschiy, A.; Kulchin, Yu. // Solid State Phenomena;2014, Vol. 213, p180 

    This paper presents the results of the study of polysaccharide chitosan as a new resist for electronic lithography for direct formation of mesostructures in submicron range. Film-forming properties of chitosan allow enough simply to obtain coatings with a thickness of tens to hundreds of...

  • Plant Polysaccharides with Immunostimulatory Activities. Paulsen, Berit Smestad // Current Organic Chemistry;Sep2001, Vol. 5 Issue 9, p939 

    Polysaccharides from plants have been the subject of study for a very long time, but mainly for their physical properties and industrial use based on these properties. Over the last 20 years there has been an ever increasing interest in the biological activity of biomolecules. These studies...

  • The Using of Ionic Gelation Method Based on Polysaccharides for Encapsulating the Macromolecules-- A Review. Usmiati, Sri; Richana, Nur; Mangunwidjaja, Djumali; Noor, Erliza; Prangdimurti, Endang // International Proceedings of Chemical, Biological & Environmenta;2014, Vol. 67, p79 

    Recently, there has been a considerable research interest in the area of bioactives delivery system using polysaccharides as non toxic biodegradable encapsulates materials. The methode to obtain encapsulates particle from those materials was using ionic gelation that has some benefits i.e. very...

  • Functionalization of biomaterials surfaces using artificial extracellular matrices. Bierbaum, Susanne; Hintze, Vera; Scharnweber, Dieter // Biomatter;Jul-Sep2012, Vol. 2 Issue 3, Special section p1 

    Construction of biomaterials with the ability to guide cell function is a topic of high interest in biomaterial development. One approach is using components native to the ECM of the target tissue to generate in vitro a microenvironment that can also elicit specific responses in cells and...

  • Coating of bioactive glass 13-93 fibres with biomedical polymers. Pirhonen, E.; Törmälä, P. // Journal of Materials Science;Apr2006, Vol. 41 Issue 7, p2031 

    The aim of this study was to coat bioactive glass 13-93 fibres with biomedical polymers. Two methods were used to coat the fibres, namely, dipping and pulling through a viscous solution. With both methods the fibres were successfully coated. Dipping was preferred for thin fibres (20–50...

  • Bioactive Ca-P coating with self-sealing structure on pure magnesium. Gan, Junjie; Tan, Lili; Yang, Ke; Hu, Zhuangqi; Zhang, Qiang; Fan, Xinmin; Li, Yangde; Li, Weirong // Journal of Materials Science: Materials in Medicine;Apr2013, Vol. 24 Issue 4, p889 

    Bioactive coatings containing Ca and P with self-sealing structures were fabricated on the surface of pure magnesium using micro-arc oxidation technique (MAO) in a specific calcium hydroxide based electrolyte system. Coatings were prepared at three applied voltages, i.e. 360, 410 and 450 V, and...

  • The Characterization and Development of Bioactive Hydroxyapatite Coatings. Ong, J. L.; Appleford, M.; Oh, S.; Yang, Y.; Chen, W.-H.; Bumgardner, J. D.; Haggard, W. O. // JOM: The Journal of The Minerals, Metals & Materials Society (TM;Jul2006, Vol. 58 Issue 7, p67 

    Bioactive coatings are currently being plasma-sprayed on implant surfaces in order to optimize bone-implant interactions. However, there are problems with the existing coating process, such as poor interfacial adhesion strength, alteration of coating properties, and the lack of an existing...

  • Bioactive glass-derived trabecular coating: a smart solution for enhancing osteointegration of prosthetic elements. Vitale-Brovarone, Chiara; Baino, Francesco; Tallia, Francesca; Gervasio, Cristina; Verné, Enrica // Journal of Materials Science: Materials in Medicine;Oct2012, Vol. 23 Issue 10, p2369 

    In this work, the use of foam-like glass-ceramic scaffolds as trabecular coatings on ceramic prosthetic devices to enhance implant osteointegration is proposed. The feasibility of this innovative device was explored in a simplified, flat geometry: glass-ceramic scaffolds, prepared by polymeric...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics