Levofloxacin and Clarithromycin Antipneumococcal Activity

Clark, C.L.; Jacobs, M.R.; Appelbaum, P.C.
December 1999
Drugs;Dec1999 Supplement 2, Vol. 58 Issue 6, p366
Academic Journal
Evaluates the activity of levofloxacin and clarithromycin against penumococci by agar dilution and microdilution in air. Breakpoints for susceptibility; Number of strains susceptible with erythromycin disk diffusion as reference.


Related Articles

  • Emergence of the M phenotype of erythromycin-resistant pneumococci in South Africa. Widdowson, Carol A.; Klugman, Keith P. // Emerging Infectious Diseases;Apr-Jun98, Vol. 4 Issue 2, p277 

    Reports on the isolation of the erythromycin-resistant pneumococci in South Africa since the year 1978. Observation of the resistance to erythromycin in pneumococci; Exhibition of most erythromycin-resistant strains; Significant increase of the M phenotype in South Africa.

  • Macrolide-Resistant Pneumococcal Endocarditis and Epidural Abscess that Develop during Erythromycin Therapy. Butler, Jay C.; Lennox, Jeffrey L.; McDougal, Linda K.; Sutcliffe, Joyce A.; Tait-Kamradt, Amelia; Tenover, Fred C. // Clinical Infectious Diseases;1/15/2003, Vol. 36 Issue 2, pe19 

    Suppurative complications of Streptococcus pneumoniae infections have become uncommon in the antibiotic era. We report a case of pneumococcal bacteremia and pneumonia complicated with epidural abscess and endocarditis in which macrolide resistance (the MLS[SUBB] phenotype) emerged during...

  • Prevalence of Macrolide Resistance Mechanisms in Streptococcus pneumoniae Isolates from a... Shortridge, Virginia D.; Doern, Gary V.; Brueggemann, Angela B.; Beyer, Jill M.; Flamm, Robert K. // Clinical Infectious Diseases;11/1/1999, Vol. 29 Issue 5, p1186 

    Discusses the prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995. Two main mechanisms of macrolide resistance described in erythromycin-resistant Streptococcus...

  • New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. Ileana Cochetti; Emily Tili; Manuela Vecchi; Aldo Manzin; Marina Mingoia; Pietro E. Varaldo; Maria Pia Montanari // Journal of Antimicrobial Chemotherapy (JAC);Jun2007, Vol. 60 Issue 1, p127 

    Objectives To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. Methods Sixteen Streptococcus pneumoniae clinical isolates sharing erm(B)-mediated erythromycin resistance and susceptibility to tetracycline...

  • Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae. Metzler, Kelli; Drlica, Karl; Blondeau, Joseph M. // Journal of Antimicrobial Chemotherapy (JAC);Mar2013, Vol. 68 Issue 3, p631 

    Background Previous work showed a higher prevalence of macrolide/azalide resistance in provinces of Canada where azithromycin was the major treatment for Streptococcus pneumoniae as compared with regions where clarithromycin was the dominant treatment. These data provided a way to test the...

  • Molecular characteristics of erythromycin-resistant Streptococcus pneumoniae from pediatric patients younger than five years in Beijing, 2010. Lin Zhou; Xiang Ma; Wei Gao; Kai-hu Yao; A-dong Shen; Sang-jie Yu; Yong-hong Yang // BMC Microbiology;2012, Vol. 12 Issue 1, p228 

    Background: Streptococcus pneumoniae is the main pathogen that causes respiratory infections in children younger than five years. The increasing incidence of macrolide- and tetracycline-resistant pneumococci among children has been a serious problem in China for many years. The molecular...

  • Postantibiotic Effect of Levofloxacin Against Pneumococci. Spangler, S.K.; Lin, G.; Jacobs, M.R.; Appelbaum, P.C. // Drugs;Dec1999 Supplement 2, Vol. 58 Issue 6, p378 

    Tests the postantibiotic effect (PAE) and PAE-sub-MIC (SME) of levofloxacin, ofloxacin, ciprofloxacin, erythromycin, azithromycin and clarithromycin against several pneumococci. Measurement of the PAE-SME; Exposure to antibiotics.

  • In Vitro Activity of New Cephalosporins vs Streptococcus pneumoniae from the Canadian Bacterial Surveillance Network: 2008-2011. McGeer, Allison; Patel, Samir; Low, Donald; Green, Karen; Rudnick, Wallis; Pong-Porter, Sylvia // Current Microbiology;Nov2014, Vol. 69 Issue 5, p763 

    Between 2008 and 2011, 6,895 Streptococcus pneumoniae isolates were submitted to the Canadian Bacterial Surveillance Network and underwent in vitro susceptibility testing. Fifteen percent of S. pneumoniae isolates were collected from pediatric patients (0-15 years old), 48.6 % of isolates were...

  • Antimicrobial Use and Colonization with Erythromycin-Resistant Streptococcus pneumoniae in... Syrogiannopoulos, George A.; Grivea, Ioanna N.; Davies, Todd A.; Katopodis, George D.; Appelbaum, Peter C.; Beratis, Nicholas G. // Clinical Infectious Diseases;10/1/2000, Vol. 31 Issue 4, p887 

    Evaluates nasopharyngeal colonization with erythromycin-resistant Streptococcus pneumoniae during the first two years of life in central and southern Greece. Relationship between carriage of erythromycin-resistant pneumococci and use of macrolides or beta-lactams in the previous three months;...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics