Helicobacter pylori Eradication in Patients with Non-Ulcer Dyspepsia

Xia, H.H-X.; Talley, N.J.
November 1999
Drugs;Nov1999, Vol. 58 Issue 5, p785
Academic Journal
Epidemiological and pathophysiological studies, as well as clinical trials, attempting to identify a relationship between Helicobacter pylori infection and non-ulcer dyspepsia (NUD), or a subset of NUD, have produced inconsistent and confusing results. While it is possible that H. pylori eradication may be beneficial for symptom relief in a small proportion of patients, routine H. pylori testing and treatment in documented NUD is not currently widely accepted. Despite the lack of convincing evidence, the European Helicobacter pylori Study Group, an Asian Pacific Consensus Meeting, the American Digestive Health Foundation and the American Gastroenterology Association have all recommended considering H. pylori eradication in patients with NUD on a patient-by-patient basis. Recently, large prospective, randomised, double-blind, controlled clinical trials applying highly effective antimicrobial therapy have been conducted with 12 months follow-up. Although these well-designed studies have reached differing conclusions, the results have been largely negative. H. pylori eradication therapy in NUD will fail to relieve symptoms in most patients in the long term.


Related Articles

  • Influence of Helicobacter pylori infection on in vitro responsiveness of gastric fundus to agonists and to stimulation of enteric nerves in Mongolian gerbils. Takehara, Yusuke; Mizuta, Yohei; Isomoto, Hajime; Ohnita, Ken; Yoshimura, Masaya; Nakamura, Takashi; Takeshima, Fuminao; Omagari, Katsuhisa; Murase, Kunihiko; Murata, Ikuo; Taniyama, Kohtaro; Kohno, Shigeru // Journal of Gastroenterology;2002, Vol. 37 Issue 8, p589 

    Background. It has recently been proposed that disturbed gastric adaptive relaxation may play a role in functional dyspepsia (FD). However, the effect of Helicobacter pylori infection, which may be one of multiple factors associated with FD, on gastric relaxation is not clear. The aim of this...

  • AKT answer relating to management of dyspepsia.  // InnovAiT;Apr2011, Vol. 4 Issue 4, p244 

    The article offers information on how to manage dyspepsia which involves the use of a proton pump inhibitor (PPI) or test and treat for helicobacter pylori (H. pylori) and the prescription of a prokinetic or an H2-receptor antagonist for one month.

  • Eradicting Helicobacter pylori and symptoms of non-ulcer dyspepsia. Patchett, S.; Beattie, S.; Leen, E.; Keane, C.; O'Morain, C. // BMJ: British Medical Journal (International Edition);11/16/91, Vol. 303 Issue 6812, p1238 

    Examines the effects of Helicobacter pyroli eradication on non-ulcer dyspepsia symptoms in Adelaide, South Australia. Role of H. pyroli in the development of gastritis; Use of questionnaire in determining the change in symptoms scores of patients; Microbiological evidence on the presence of H....

  • Is Helicobacter pylori the cause of dyspepsia? Bernersen, Bjorn; Johnsen, Roar; Bostad, Leif; Straume, Bjorn; Sommer, Ann-Inger; Burhol, Per G. // BMJ: British Medical Journal (International Edition);5/16/92, Vol. 304 Issue 6837, p1276 

    Examines the association between infection with Helicobacter (H) pylori and dyspepsia in Norway. Factors causing the prevalence of the disease; Methodology of the treatment; Investigation on the occurrence of endoscopic and histological diagnoses of cultures positive with H. pylori.

  • Noninvasive Helicobacter pylori testing was as effective as endoscopy for managing dyspepsia. Delaney, Brendan // ACP Journal Club;Jan/Feb2003, Vol. 138 Issue 1, p16 

    Focuses on a study that examined the effectiveness of noninvasive Helicobacter pylori as endescopy for managing dyspepsia. Description of the clinical characteristics of patients; Patient intervention; Outcome measures.

  • Helicobacter pylori eradication improved dyspepsia symptoms.  // ACP Journal Club;Jan/Feb2003, Vol. 138 Issue 1, p17 

    Presents a study which investigated the role of Helicobacter pylori eradication in improving dyspepsia symptoms. Description of the clinical characteristics of patients; Patient intervention; Outcome measures.

  • Role of Helicobacter pylori in Functional Dyspepsia: More Controversies Than Answers. Yeong Yeh Lee; Andrew Seng Boon Chua // Journal of Neurogastroenterology & Motility;Jul2013, Vol. 19 Issue 3, p417 

    A letter to the editor is presented in response to the article "Effect of Helicobacter pylori eradication on functional dyspepsia" by S.E. Kim and colleagues in a 2013 issue. of the journal.

  • No evidence that nonulcer dyspepsia is caused by H pylori.  // Modern Medicine;Jun95, Vol. 63 Issue 6, p34 

    Presents an abstract of the article `Nonulcer Dyspepsia in a Dutch Working Population and Helicobacter pylori: Ulcer History as an Explanation of an Apparent Association,' by R.J. Schlemper, S.D.J. van der Werf, et al., which was published in the `Archives of Internal Medicine' dated January 9,...

  • Before you order endoscopy, screen for H pylori, NSAID use, `sinister symptoms'.  // Modern Medicine;Apr96, Vol. 64 Issue 4, p41 

    Presents an abstract of the article entitled `Prospective screening of dyspeptic patients by Helicobacter pylori serology,' by P. Patel, S. Khulusi, M.A. Mendall, et al. which was published in the November 18, 1995 issue of `Lancet.'


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics