TITLE

Valsartan/Hydrochlorothiazide

AUTHOR(S)
Langtry, H.D.; McClellan, K.J.
PUB. DATE
May 1999
SOURCE
Drugs;May1999, Vol. 57 Issue 5, p751
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
â–´ Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. â–´ HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy, HCTZ pharmacokinetics differed from those seen with HCTZ monotherapy. â–´ In clinical trials in patients with essential hypertension, adding HCTZ 12.5 or 25 mg/day to valsartan 80 mg/day resulted in a greater blood pressure reduction than increasing the valsartan dosage from 80 to 160 mg/day. â–´ The valsartan/HCTZ combination was generally more effective than either drug given alone. Efficacy of the combination was maintained during up to 3 years of treatment. â–´ Valsartan/HCTZ was well tolerated in both short and long term trials. The most common adverse events were dizziness, headache and fatigue. The overall incidence of adverse events with the combination was similar to that with placebo. HCTZ-induced hypokalaemia was less common during combination therapy.
ACCESSION #
9593212

 

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