TITLE

HMG-CoA Reductase Inhibitors in the Prevention of Stroke

AUTHOR(S)
van Mil, A.H.M.; Westendorp, R.G.J.; Bollen, E.L.E.M.; Lagaay, A.M.; Blauw, G.J.
PUB. DATE
January 2000
SOURCE
Drugs;Jan2000, Vol. 59 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Stroke is a heterogeneous disorder, with the definition including both haemorrhagic and ischaemic stroke. Although these subtypes of stroke have different underlying pathophysiological mechanisms, atherosclerosis plays a pivotal role in both. Most risk factors for cardiovascular disease are also risk factors for stroke. Patients with a history of cardiovascular events are at an increased risk of stroke. Although hypercholesterolaemia is the most characteristic risk factor for atherosclerotic diseases, recent data suggest that the correlation between cholesterol levels and either ischaemic or haemorrhagic stroke is weak. However, the interpretation of these results is hampered by the inconsistent use of classifications of the various subtypes of stroke in studies. Pooled data on the effect of HMG-CoA reductase inhibitors show a 30% risk reduction in strokes. These beneficial effects are obtained from studies in middle aged patients with ischaemic heart disease, the interpretation being that the effects of HMG-CoA reductase inhibitors on stroke are mediated via (i) cholesterol-lowering effects on the coronary vasculature or (ii) cholesterol-independent effects of these agents. The results cannot be extrapolated to the elderly, among whom stroke most frequently occurs.
ACCESSION #
9592958

 

Related Articles

  • Stopping Statins in At-Risk Patients -- Just Too Risky.  // Internal Medicine Alert;10/15/2007, Vol. 29 Issue 19, p1 

    The article reports that stopping statins after stroke or cardiovascular surgery increases vascular complications according to three studies.

  • Statin Withdrawal May Lead to Adverse Outcomes in Acute Stroke. Segal, Alan Z. // Internal Medicine Alert;11/15/2007, Vol. 29 Issue 21, p164 

    STATIN THERAPY HAS A WELL-RECOGNIZED ROLE IN the primary and secondary prevention of stroke. Statins may also have a neuroprotective effect in the setting of acute stroke. This has been well documented in animal models and high dose acute statin therapy is currently under investigation in human...

  • Statins prevent stroke in high-risk patients. Collins, R.; Armitage, J.; Parish, S. // Journal of Family Practice;Jul2004, Vol. 53 Issue 7, p522 

    Discusses an abstract of "Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20,536 people with cerebrovascular disease or other high-risk conditions," by R. Collins et al published in a 2004 issue of "Lancet" journal.

  • Efficacy of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for prevention of stroke. Warshafsky, Stephen; Packard, David; Marks, Stephen J.; Sachdeva, Neeraj; Terashita, Dawn M.; Kaufman, Gabriel; Sang, Koky; Deluca, Albert J.; Peterson, Stephen J.; Frishman, William H.; Warshafsky, S; Packard, D; Marks, S J; Sachdeva, N; Terashita, D M; Kaufman, G; Sang, K; Deluca, A J; Peterson, S J; Frishman, W H // JGIM: Journal of General Internal Medicine;Dec1999, Vol. 14 Issue 12, p763 

    Objective: To determine if 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in preventing fatal and nonfatal strokes in patients at increased risk of coronary artery disease.Design: Meta-analysis of randomized controlled...

  • Half of high-risk patients missing out on statins.  // Pulse;3/24/2003, Vol. 63 Issue 12, p19 

    Discusses the results of a study showing that patients at risk of coronary heart disease and stroke are missing out on statins or cholesterol-lowering therapy. Trends in statin prescribing from 1994 to 2001 in patients being treated for blocked and narrow arteries; Standardized prescribing of...

  • Statin Treatment Not Unked to Intracerebral Hemorrhage After Ischemic Stroke.  // Neurology Reviews;Oct2011, Vol. 19 Issue 10, p39 

    The article reports on the study by assistant professor Daniel G. Hackam and colleagues which shows that statin treatment after acute ischemic stroke is not linked to intracerebral hemorrhage (ICH).

  • Benefits of statins in stroke vary based on cerebrovascular history. Gupta, Eric // Cardiology Today;Apr2009, Vol. 12 Issue 4, p7 

    The article focuses on a research which confirmed that statins are effective in reducing stroke, but these effects vary based on prior history of cerebrovascular disease.

  • JUPITER results favorable for patients with stroke.  // Cardiology Today;Apr2009, Vol. 12 Issue 4, p14 

    The article reports that a recent multicenter statin trial has found that rosuvastatin reduced the total incidence of stroke and cardiovascular endpoints in patients with stroke.

  • Statin use does not raise bleed risk after stroke.  // Pulse;9/21/2011, Vol. 71 Issue 30, p11 

    The article reports on the unlikely connection between statin use and intracerebral haemorrhage in patients who have previously had an ischaemic stroke.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics