TITLE

Concurrent Gonococcal and Chlamydial Infection: How Best to Treat

AUTHOR(S)
Robinson, A.J.; Ridgway, G.L.
PUB. DATE
April 2000
SOURCE
Drugs;Apr2000, Vol. 59 Issue 4, p801
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Clinicians treating concurrent gonococcal and chlamydial infections have a variety of drugs to choose from. Neisseria gonorrhoeae is adept at developing resistance and the choice of antibiotic must be dictated to some extent by the patterns of resistance in the locality of the clinician. In contrast, resistance of Chlamydia trachomatis to some classes of drugs has been shown in vitro but does not appear to be clinically important at present. The success of treatment depends on patient compliance with the drug administration schedule. With these organisms, which can be carried asymptomatically, many patients are unlikely to comply with courses of antibiotics. Although single-dose therapy with azithromycin is available and established for chlamydial genital infection, it is more expensive and difficult to justify in a cash limited Healthcare system, and its efficacy for treating concurrent gonococcal infection requires further study. In patients where compliance is likely to be of concern, its use may be justified. Another major deterrent for completing antibiotic courses is the adverse effect profile. Most of the available drugs cause only minor adverse effects, in particular gastrointestinal. Ofloxacin has a better profile than doxycycline but is considerably more expensive. Newer fluoroquinolones, found to be effective in vitro, are being assessed in clinical studies. However, more evidence is required before recommending these over the tried and tested therapies.
ACCESSION #
9592786

 

Related Articles

  • High-risk sexual behaviours and genital chlamydial infections in high school students in Southern Taiwan. Hsieh, V.-H.; Shih, T.-Y.; Lin, H.-W.; Hsieh, T.-C.; Kuo, M.-J.; Lin, C.-W.; Gaydos, C. A. // International Journal of STD & AIDS;Apr2010, Vol. 21 Issue 4, p254 

    The objective of this study was to determine the prevalence of high-risk sexual behaviours and sexually transmitted infections (STIs) and associated risk factors in Taiwanese high school students. Students in grades 10 and 11 (mean age: 15.9 ± 0.9; range: 13-20 years) at two schools were...

  • Fluoroquinolone resistance in neisseria gonorrhoeae. Knapp, Joan S.; Fox, Kimberley K. // Emerging Infectious Diseases;Jan-Mar97, Vol. 3 Issue 1, p33 

    Reports that Neisseria gonorrhoeae is clinically significant resistant to broad-spectrum cephalosporins and fluoroquinolone. Effectiveness of fluoroquinolone and broad-spectrum cephalosporins in gonorrhea treatment; Decreased susceptibility of strains from Far Eastern countries to fluoroquinolones.

  • Fluoroquinolone-resistant Neisseria gonorrhoeae-San Diego, California, 1997.  // MMWR: Morbidity & Mortality Weekly Report;5/29/1998, Vol. 47 Issue 20, p405 

    Presents the results of an investigation conducted in 1997, on two cases of gonococcal infection in the United States which had strains of high levels of fluoroquinolone resistance. Information on two case studies reported on two young men with a two-day history of purulent urethral discharge;...

  • A shorter course of antibiotic is effective for chlamydial cervicitis.  // Modern Medicine;Jul96, Vol. 64 Issue 7, p11 

    Reports that a shorter course of antibiotic is effective for the treatment of uncomplicated chlamydial cervicitis according to Mark B. Reedy and colleagues who presented the results of their study during the 1996 annual meeting of the American College of Obstetricians and Gynecologists. ...

  • Overall, azithromycin is cost-effective for treating chlamydial infections.  // Modern Medicine;Jul96, Vol. 64 Issue 7, p61 

    Presents an abstract on the article `Doxycycline Compared With Azithromycin for Treating Women With Genital Chlamydia Trachomatis Infections: An Incremental Cost-Effectiveness Analysis,' by D. Magid, J.M. Douglas Jr. et al published in the February 15, 1996 issue of the `Internal Medicine' journal.

  • Chlamydial perihepatitis (Curtis-Fitz-Hugh-syndrome) after hydrotubation. Simson, Jay N.L. // British Medical Journal (Clinical Research Edition);9/1/1984, Vol. 289 Issue 6444, p544 

    Presents a case on the Chlamydial perihepatitis after hydrotubation. Symptoms of the disease; Cause of the biliary-type pain; Application of chlamydial serology.

  • body.  // BOYZ;4/1/2010, Issue 970, p74 

    The article offers information on the symptoms of Chlamydia and Lymphogranuloma venereum (LGV) and how to avoid treat it.

  • Assessment of antichlamydial effects of a novel polyherbal tablet Basant. Bhengraj, A. R.; Goyal, A.; Talwar, G. P.; Mittal, A. // Sexually Transmitted Infections;Dec2009, Vol. 85 Issue 7, p561 

    An abstract of the article "Assessment of antichlamydial effects of a novel polyherbal tablet Basant," by A. R. Bhengraj, A. Goyal and G. P. Talwar is presented.

  • Chlamydia buster. Brody, Liz // Shape;Mar92, Vol. 11 Issue 7, p23 

    Focuses on the effectiveness of azithromycin in controlling chlamydia.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics