TITLE

Clinical features and diagnosis of autoimmune hepatitis - primary biliary cirrhosis overlap syndrome

AUTHOR(S)
LI Bing; SHAO Qing; NIU Xiaoxia
PUB. DATE
May 2014
SOURCE
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi;2014, Vol. 30 Issue 5, p413
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To analyze the clinical features and laboratory test results of patients with autoimmune hepatitis ( AIH ) - primary biliary cirrhosis (PBC) overlap syndrome, as well as their correct diagnosis rate and time to diagnosis. Methods Fifty - three patients who were diagnosed by liver biopsy as having AIH - PBC overlap syndrome from January 2009 to June 2013 were selected as subjects; 53 AIH patients and 53 PBC patients were selected as control groups. Their clinical manifestations, laboratory test results, and diagnosis on admission were retrospectively analyzed. Comparison of normally distributed quantitative data between groups was made by one - way analysis of variance, and multiple comparisons were made by SNK - q test ; comparison of qualitative data between groups was made using RxC contingency table, and multiple comparisons were made by Scheffe's confidence interval test. Results The 53 patients with AIH - PBC overlap syndrome had a serum alanine aminotransferase level of 173. 65 ±52. 08 U/L, a serum total bilirubin level of 38. 07 ± 6. 82 μmo/L, a serum alkaline phosphatase ( ALP) level of 293. 81 ± 28. 89 U/L, and a serum gamma - glutamyl transpeptidase level of 57. 57 ±78. 84 U/L. ALP showed significant difference between the patients with AIH - PBC overlap syndrome and control groups. The serum level of immunoglobulin M in overlap syndrome patients was 3. 33 ±2. 12 g/L, which was significantly different from those of two control groups. Of the 53 overlap syndrome patients, 27 were positive for anti - mitochondrial antibody - M2, and the positive rate was significantly different from those of two control groups. Without liver biopsy, the correct diagnosis rate was the lowest (52. 83% ), and it took the longest time (8 ±7.7 d) to confirm the diagnosis on admission. Conclusion The clinical manifestations of patients with AIH - PBC overlap syndrome are more similar to those of PBC patients, but their biochemical test results are more similar to those of AIH patients. AIH - PBC overlap syndrome has the clinical features of both AIH and PBC.
ACCESSION #
95911110

 

Related Articles

  • Significance of clinical pathology in diagnosis and treatment of autoimmune liver diseases. MIAO Qi; MA Xiong // Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi;2014, Vol. 30 Issue 5, p385 

    Liver biopsy plays an important role in the diagnosis of autoimmune liver diseases, particularly in patients without specific clinical manifestations or negative for autoantibodies. The histological features of several autoimmune liver diseases are reviewed. The characteristic features of...

  • The utility of IgG, IgM, and CD138 immunohistochemistry in the evaluation of autoimmune liver diseases. Abe, Kazumichi; Takahashi, Atsushi; Nozawa, Yoshihiro; Imaizumi, Hiromichi; Hayashi, Manabu; Okai, Ken; Kanno, Yukiko; Watanabe, Hiroshi; Ohira, Hiromasa // Medical Molecular Morphology;Sep2014, Vol. 47 Issue 3, p162 

    Primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) present with distinct clinical features. The term 'PBC-AIH overlap syndrome (OS)' has been adopted to describe the condition characterized by occurrence of both PBC and AIH, although this clinical entity is difficult to define. This...

  • Low incidence of positive smooth muscle antibody and high incidence of isolated IgM elevation in Chinese patients with autoimmune hepatitis and primary biliary cirrhosis overlap syndrome: a retrospective study. Pan Zhao; Yukun Han // BMC Gastroenterology;2012, Vol. 12 Issue 1, p1 

    Background: Up to now, few data are available regarding the clinical characteristics of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome. The study was to investigate and analyze the prevalent and clinical features of Chinese patients with this disease. Methods: Clinical data...

  • Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature. Invernizzi, Pietro; Grazia Alessio, Maria; Smyk, Daniel S.; Lleo, Ana; Sonzogni, Aurelio; Fabris, Luca; Candusso, Manila; Bogdanos, Dimitrios P.; Iorio, Raffaele; Torre, Giuliano // BMC Gastroenterology;2012, Vol. 12 Issue 1, p92 

    Background: Unlike other autoimmune liver diseases, primary biliary cirrhosis (PBC) has never been reported in early childhood, while type 2 autoimmune hepatitis (AIH) is eminently a paediatric disease. Case presentation: We describe a case of type 2 AIH with serological positivity for...

  • Autoimmune Hepatitis Overlapping With Primary Sclerosing Cholangitis in Five Cases. McNair, Alistair N. B.; Moloney, Manus; Portmann, Bernard C.; Williams, Roger; McFarlane, Ian G. // American Journal of Gastroenterology;May1998, Vol. 93 Issue 5, p777 

    Objective: We report five cases (four male; median age 20 yr, range 14-38 yr) of an autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome. The patients presented with jaundice, elevated serum aminotransferase and alkaline phosphatase activities, hyperglobulinemia with high...

  • Bezafibrate treatment: a new medical approach for PBC patients? Kanda, Tatsuo; Yokosuka, Osamu; Imazeki, Fumio; Saisho, Hiromitsu // Journal of Gastroenterology;2003, Vol. 38 Issue 6, p573 

    Background. A new medical approach to primary biliary cirrhosis (PBC) has been desired. We investigated the feasibility of using combination ursodeoxycholic acid (UDCA)-bezafibrate therapy in patients with PBC non-responsive to UDCA monotherapy. Methods. During a 6-month period, 22 PBC patients...

  • The abdominal manifestations of the antiphospholipid syndrome. Uthman, I.; Khamashta, M. // Rheumatology;Nov2007, Vol. 46 Issue 11, p1641 

    Objectives. To study the abdominal manifestations of the antiphospholipid syndrome (APS).

  • Procollagen--III Peptide and Chronic Viral C Hepatitis. Jeffers, Lennox J.; Coelho-Littte, M. Ester; Cheinquer, Hugo; Vargas, Carlos; Civantos, Francisco; Alvarez, Luis; Reddy, K. Rajender; Parker, Talley; De Medina, Maria; Xiuming Li; Hill, Mary; LaRue, Silvia; Schiff, Eugene R. // American Journal of Gastroenterology;Sep1995, Vol. 90 Issue 9, p1437 

    Chronic hepatitis develops in at least half of persons acutely infected with hepatitis C virus (HCV), Ten to 25% of these patients will develop cirrhosis. Serum pro-collagen-III peptide (PIIIP) may be of value in predicting the development of chronic active fibrogenic liver disease. It has been...

  • Predictive Factors for Hepatocellular Carcinoma in Type 1 Autoimmune Hepatitis. Montano-Loza, Aldo J.; Carpenter, Herschel A.; Czaja, Albert J. // American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p1944 

    OBJECTIVE: Hepatocellular carcinoma (HCC) is an uncommon but serious occurrence in autoimmune hepatitis. Our objective was to determine predictors for this neoplasm to improve screening strategies. METHODS: Two hundred twenty-seven patients underwent hepatic ultrasonography and serum alpha...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics