TITLE

Effects of Afala and Antiestrogen ICI 182,780 in the Model of Hormone-Dependent Prostate Inflammation

AUTHOR(S)
Bernoulli, J.; Konkol, Y.; Vuorikoski, H.; Yatkin, E.
PUB. DATE
April 2014
SOURCE
Bulletin of Experimental Biology & Medicine;Apr2014, Vol. 156 Issue 6, p807
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the hormone-dependent prostate inflammation model induced by implantation of slowreleasing pellets (50 mg testosterone and 5 mg estradiol) to Noble male rats, intragastric administration of Afala at a dose of 7.5 ml/kg for 18 weeks reduced the number of inflamed prostatic acini. The effect of afala was comparable with that of antiestrogen ICI 182,780 (3 mg/kg subcutaneously twice a week for 18 weeks). Prolonged treatment with hormones in high doses induced severe inflammation of the prostate tissue, which was not terminated by the test preparations. As differentiated from the antiestrogen ICI 182,780, afala did not induce body weight gain and decrease in pituitary weight in experimental animals in comparison with the control group.
ACCESSION #
95905690

 

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