TITLE

SPECT/CT for tumour imaging

AUTHOR(S)
Fettich, Jure; Hodolič, Marina
PUB. DATE
July 2013
SOURCE
Archive of Oncology;2013, Vol. 21 Issue 2, p121
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hybrid imaging combining PET and CT is standard technique already for many years. Now it is becoming state of the art nuclear medicine technique also in the field of single photon emission tomography (SPECT) as SPECT/CT. Advantages of hybrid imaging are improved quality of the images using CT data for attenuation correction based on true transmission density data in the individual patient, and CT and SPECT fusion images providing accurate localisation of the tracer uptake. The former is useful in dosimetric calculation in case of tumours treated by radiopharmaceuticals emitting also gamma photons such as 177-Lu. Accurate localisation of increased tracer uptake is important especially in the diagnostic of tumours. This can improve specificity of tumour imaging, for example differentiation between abnormal uptake in the primary tumour and uptake in the metastasis in a lymph node. In this respect hybrid imaging can improve the accuracy of staging and evaluation of treatment follow-up. In several areas single photon emitting radiopharmaceuticals need to be used since there are no useful PET tracers available. This is true in case of neuroendocrine tumours, adrenal tumours, atypical haemangiomas etc., and also in case of benign parathyroid adenomas or osteoid osteomas when radioguided surgery using gamma probe is considered. Lymphoscintigraphy for radioguided sentinel node scintigraphy has become standard in various types of cancers. If exact localisation of the sentinel node can be shown on a fused image this is certainly a big help for the surgeon performing biopsy. The ability of SPECT/CT to improve diagnostic accuracy, especially specificity has great potential in further grow of nuclear medicine techniques in evaluation of tumours.
ACCESSION #
95747969

 

Related Articles

  • The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI. Bernsen, Monique; Vaissier, Pieter; Holen, Roel; Booij, Jan; Beekman, Freek; Jong, Marion // European Journal of Nuclear Medicine & Molecular Imaging;May2014 Supplement, Vol. 41, p36 

    Preclinical imaging with SPECT combined with CT or MRI is used more and more frequently and has proven to be very useful in translational research. In this article, an overview of current preclinical research applications and trends of SPECT combined with CT or MRI, mainly in tumour imaging and...

  • SPECT/CT and tumour imaging. Abikhzer, Gad; Keidar, Zohar // European Journal of Nuclear Medicine & Molecular Imaging;May2014 Supplement, Vol. 41, p67 

    Scintigraphic techniques are sensitive imaging modalities in the diagnosis and follow-up of cancer patients providing the functional and metabolic activity characteristics of the tumour. Hybrid SPECT/CT improves the diagnostic accuracy of these well-established imaging techniques by precise...

  • Nuclear medicine imaging of neuroendocrine tumours. Al-Nahhas, Adil // Clinical Medicine;Aug2012, Vol. 12 Issue 4, p377 

    The article discusses nuclear medicine imaging of neuroendocrine tumours (NETs), a clinically diverse group of tumours which commonly affect the gastroenteropancreatic tract and lungs. NETs comprise carcinoid tumours and various pancreatic tumours such as gastrinoma, insulinoma, VIPoma,...

  • Ga-DOTATOC PET/CT provides accurate tumour extent in patients with extraadrenal paraganglioma compared to I-MIBG SPECT/CT. Kroiss, Alexander; Shulkin, Barry; Uprimny, Christian; Frech, Andreas; Gasser, Rudolf; Url, Christoph; Gautsch, Kurt; Madleitner, Ruth; Nilica, Bernhard; Sprinzl, Georg; Gastl, Guenther; Fraedrich, Gustav; Virgolini, Irene // European Journal of Nuclear Medicine & Molecular Imaging;Jan2015, Vol. 42 Issue 1, p33 

    Purpose: The aim of this study was to compare the accuracy of I-MIBG SPECT/CT with that of Ga-DOTATOC PET/CT for staging extraadrenal paragangliomas (PGL) using both functional and anatomical images (i.e. combined cross-sectional imaging) as the reference standards. Methods: The study included...

  • Selectively false-positive radionuclide scan in a patient with sarcoidosis and papillary thyroid cancer: a case report and review of the literature. Lebo, Nicole L.; Raymond, Francois; Odell, Michael J. // Journal of Otolaryngology -- Head & Neck Surgery;2015, Vol. 44 Issue 1, p1 

    Background: Radioiodine and Tc-99 m pertechnetate scans are routinely relied upon to detect metastasis in papillary thyroid cancer; false-positive scans are relatively rare. To our knowledge, no published reports exist of sarcoidosis causing such selectively false-positive scans. Methods: We...

  • Case Report of Tc-99m Sulfur Colloid Single-Photon Emission Computed Tomography/Computed Tomography Study Differentiating Tumor from Accessory Spleen. Aggarwal, Reena; Wagner, Thomas; Navalkissoor, Shaunak // World Journal of Nuclear Medicine;Sep2013, Vol. 12 Issue 3, p129 

    We present a case report where Tc-99m sulfur colloid single-photon emission computed tomography (SPECT)/computed tomography (CT) scan was useful in characterizing a soft tissue abdominal mass and helped with patient management. A 63-year-old male with no previous history of trauma had an...

  • EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2. Kapucu, Özlem; Nobili, Flavio; Varrone, Andrea; Booij, Jan; Borght, Thierry; Någren, Kjell; Darcourt, Jacques; Tatsch, Klaus; Laere, Koen // European Journal of Nuclear Medicine & Molecular Imaging;Dec2009, Vol. 36 Issue 12, p2093 

    These guidelines summarize the current views of the European Association of Nuclear Medicine Neuroimaging Committee (ENC). The purpose of the guidelines is to assist nuclear medicine practitioners when making recommendations, performing, interpreting, and reporting the results of brain perfusion...

  • Editorial. Kamiński, Grzegorz // Nuclear Medicine Review;2013, Vol. 16 Issue 1, p1 

    No abstract available.

  • Improved Benefit of SPECT/CT Compared to SPECT Alone for the Accurate Localization of Endocrine and Neuroendocrine Tumors. Bural, Gonca G.; Muthukrishnan, Ashok; Oborski, Matthew J.; Mountz, James M. // Molecular Imaging & Radionuclide Therapy;Oct2012, Vol. 21 Issue 3, p91 

    Objective: To assess the clinical utility of SPECT/ CT in subjects with endocrine and neuroendocrine tumors compared to SPECT alone. Material and Methods: 48 subjects (31 women;17 men; mean age 54�11) with clinical suspicion or diagnosis of endocrine and neuroendocrine tumor had 50 SPECT/CT...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics