Clinicopathologic characteristics and survival of male breast cancer

Liu, Dongying; Xie, Guangru; Chen, Ming
April 2014
International Journal of Clinical Oncology;Apr2014, Vol. 19 Issue 2, p280
Academic Journal
Backgrounds: Male breast cancer (MBC) is a rare disease and accounts for <1 % of all breast cancers. Methods: We retrospectively analyzed clinicopathologic characteristics and prognosis of MBC patients who were diagnosed in our hospital between March 2002 and March 2012. Results: The median age of diagnosis of MBC was 62 years, which was 9 years older than female breast cancer (FBC) patients. The highest proportion of MBC patients was in the 50-59-year age group. The percentage of invasive ductal carcinoma in MBC was much higher than in FBC ( P = 0.000). The positive rate of estrogen receptors in MBC patients (87.9 %) was significantly higher than in FBC patients ( P = 0.048), whereas HER-2 was positive in 17.2 % of MBC patients, which was significantly lower than in FBC patients ( P = 0.001). There was a consistent significant difference in luminal subtypes of FBC and MBC patients ( P = 0.000). The overall survival rates of MBC were significantly higher than FBC ( P = 0.004). HER-2-positive patients had a statistically worse prognosis than HER-2-negative patients ( P = 0.040). Lymph node metastasis and larger tumor size were also associated with poorer prognosis ( P = 0.056 and P = 0.088). The level of hormones was examined in 7 patients, and abnormal hormone levels were detected in 4. Conclusion: The FBC patients were significantly different from the MBC in clinicopathologic and prognostic characteristics. HER-2 positivity was an important factor for prognosis.


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