TITLE

The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats

AUTHOR(S)
Yidong Wei; Xiaoyu Liu; Haidong Wei; Lei Hou; Wenliang Che; Erlinda The; Gang Li; Jhummon, Muktanand Vikash; Wanlin Wei
PUB. DATE
January 2013
SOURCE
Evidence-based Complementary & Alternative Medicine (eCAM);2013, Vol. 2013, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Qiliqiangxin, a Chinese herb, represents the affection in Ca channel function of cardiac myocytes. It is unknown whether Qiliqiangxin has an effect on Na current and K current because the pharmacological actions of this herb's compound are very complex. We investigated the rational usage of Qiliqiangxin on cardiac ventricular myocytes of rats. Ventricular myocytes were exposed acutely to 1, 10, and 50 mg/L Qiliqiangxin, and whole cell patch-clamp technique was used to study the acute effects of Qiliqiangxin on Sodium current (INa), outward currents delayed rectifier outward K+ current (IK), slowly activating delayed rectifier outward K+ current (IKs), transient outward K+ current (Ito), and inward rectifier K+ current (IKI). Qiliqiangxin can decrease INa by 28.53% ± 5.98%, and its IC50 was 9.2 mg/L. 10 and 50 mg/L Qiliqiangxin decreased by 37.2% ± 6.4% and 55.9% ± 5.5% summit current density of Ito. 10 and 50 mg/L Qiliqiangxin decreased IKs by 15.51% ± 4.03% and 21.6% ± 5.6%. Qiliqiangxin represented a multi-faceted pharmacological profile. The effects of Qiliqiangxin on Na and K currents of ventricular myocytes were more profitable in antiarrhythmic therapy in the clinic. We concluded that the relative efficacy of Qiliqiangxin was another choice for the existing antiarrhythmic therapy.
ACCESSION #
95496295

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics