The Role of Activating Transcription Factor-2 in Skeletal Growth Control
- Developmental regulation of the growth plate. Kronenberg, Henry M. // Nature;5/15/2003, Vol. 423 Issue 6937, p332
Vertebrates do not look like jellyfish because the bones of their skeletons are levers that allow movement and protect vital organs. Bones come in an enormous variety of shapes and sizes to accomplish these goals, but, with few exceptions, use one process - endochondral bone formation - to...
- Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification. Wuelling, Manuela; Vortkamp, Andrea // Pediatric Nephrology;Apr2010, Vol. 25 Issue 4, p625
During endochondral ossification bones are formed as cartilage templates in which chondrocytes proliferate, differentiate into hypertrophic chondrocytes and are gradually replaced by bone. Postnatally, remnants of embryonic chondrocytes remain in a restricted domain between the ossified regions...
- The first South African International Symposium on Developmental, Cell & Molecular Biology. // South African Journal of Science;Nov/Dec96, Vol. 92 Issue 11/12, p566
Presents the abstract of the paper `Fishing with a winged-helix transcription factor for gene targets,' by E. Rumbark and N. Illing,' presented during the first South African International Symposium in Developmental, Cell and Molecular Biology held January 1996 in Johannesburg, South Africa.
- A general mechanism for transcriptional synergy by eukaryotic activators. Tianhuai Chi; Lieberman, Paul // Nature;9/21/1995, Vol. 377 Issue 6546, p254
Suggests a unifying mechanism for gene activation and synergy by acidic and non-acidic activators. Indication that synergy is manifested at the earliest stage of preinitiation complex assembly; ZEBRA as a stimulant in the mechanism of transcriptional synergy.
- Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by seru... Joliot, Veronique; Demma, Mark // Nature;2/16/1995, Vol. 373 Issue 6515, p632
Shows that the general transcription factor TFIIF is also a target for a transcriptional activator, namely serum response factor (SRF), which binds to the c-fos promoter. Use of yeast interaction assay; Binding of RAP74 subunit of TFIIF by SRF; SRF's transcriptional activation domain.
- Crystal structure of the GreA transcript cleavage factor from Escherichia coli. Stebbins, Charles E.; Borukhov, Sergei // Nature;2/16/1995, Vol. 373 Issue 6515, p636
Reports the crystal structure of GreA at 2.2 ... resolution. Amino-terminal domain contained in structure; Direct role of site near tip of coiled-coil `finger' in transcript cleavage reaction; Exhibition of unusual asymmetric charge distribution.
- Discovering multiple realistic TFBS motifs based on a generalized model. // BMC Bioinformatics;2009, Vol. 10, p321
Background: Identification of transcription factor binding sites (TFBSs) is a central problem in Bioinformatics on gene regulation. de novo motif discovery serves as a promising way to predict and better understand TFBSs for biological verifications. Real TFBSs of a motif may vary in their...
- Transcription factor site dependencies in human, mouse and rat genomes. // BMC Bioinformatics;2009, Vol. 10, p339
Background: It is known that transcription factors frequently act together to regulate gene expression in eukaryotes. In this paper we describe a computational analysis of transcription factor site dependencies in human, mouse and rat genomes. Results: Our approach for quantifying tendencies of...
- Molecular Markers of Endometrial Epithelial Cell Mitogenesis Mediated by the Sp/Kr�ppel-Like Factor BTEB1. Simmen, Rosalia C.M.; Zhang, Xue-Lian; Michel, Frank J.; Min, Seok Hong; Zhao, Ge; Simmen, Frank A. // DNA & Cell Biology;Feb2002, Vol. 21 Issue 2, p115
Basic transcription element binding (BTEB1) protein is one of at least 20 Sp/KLF family members that function as transcriptional activators or repressors by binding to GC/GT-rich sequences within target genes to influence cellular homeostasis in mammals. Previously, we demonstrated that...