TITLE

Human genetics and disease: Mouse models of male infertility

AUTHOR(S)
Cooke, Howard J.; Saunders, Philippa T. K.
PUB. DATE
October 2002
SOURCE
Nature Reviews Genetics;Oct2002, Vol. 3 Issue 10, p790
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
ACCESSION #
9534374

 

Related Articles

  • Unilateral cryptorchidism appears to compromise paternity. Kuznar, Wayne // Urology Times;Feb98, Vol. 26 Issue 2, p22 

    Reports on the finding that compromised spermatogenesis is one possible explanation for decreased paternity among formerly unilateral cryptorchid men. Infertility rate of 10 percent among men who had surgical correction of an undescended testis a few months after birth to age 14; Higher...

  • Spermatogonial stem cell research results encouraging. Guttman, Cheryl // Urology Times;May2000, Vol. 28 Issue 5, p24 

    Reports that ongoing studies are providing researchers with an improved understanding of spermatogenesis that may lead to new approaches for male infertility management and gene therapy, according to David J. Cozzolino, a fellow in reproductive medicine and surgery. Research showing how...

  • Ooplasmic round spermatid nuclear injection procedures as an experimental treatment... Yamanaka, Keiko; Sofikitis, Nikolaos V. // Journal of Assisted Reproduction & Genetics;Jan97, Vol. 14 Issue 1, p55 

    Applies ooplasmic round spermatid nuclear injections for the treatment of nonobstuctive azoospermia. Includes the outcome of human ooplasmic round spermatid nuclear injections; Identification of cells isolated as round spermatids of stages 2 to 7 of spermiogenesis using electron microscopy and...

  • Examination of Idiopathic Infertility in the Presence of Normal FSH Levels.  // Fertility Weekly;1/14/2002, p16 

    Evaluates the hypophyso-gonadal axis by measuring the intratesticular concentrations of several steroids in relation with the serum hormonal status by researchers in France. Analysis on the role of testosterone and follicle stimulating hormone; Measurement of the steroid levels in testicular...

  • Polymorphisms of MSY2 Gene may be Linked to Impaired Spermatogenesis.  // Fertility Weekly;6/2/2008, p8 

    The article presents a study which assesses the potential relationship of MSY2 gene to idiopathic male infertility in China. The study reveals that allele C and G appeared to have a protective function against spermatogenic impairment. It concludes that MSY2 polymorphisms might be associated...

  • Patterns Of Testicular Histopathology In Men With Primary Infertility. Rashed, Mona M.; Ragab, Noha M.; Shalaby, Ahmad R.; Ragab, Waleed K. // Internet Journal of Urology;2008, Vol. 5 Issue 2, p11 

    Male infertility contributes to more than half of all cases of childlessness; yet, it is a reproductive health problem that is poorly studied and understood. The present study aims at the histopthological re-evaluation of the archived testicular biopsy specimen in order to delineate the...

  • Can sperm count increase in six to eight weeks? Sah, Purushottam // Internet Journal of Endocrinology;2010, Vol. 6 Issue 1, p1 

    Medical therapy for oligospermia is usually given for a minimum period of three months, so that it covers a complete spermatogenic cycle. One experimental study shows that spermatogenic cycles may be shorter, about sixty days, in men. Here clinical data of five oligospermic men are presented to...

  • Review of Meiotic Chromosome Abnormalities.  // Fertility Weekly;11/20/2006-11/27/2006, p8 

    The article highlights the results of a study focusing on meiotic chromosome abnormalities in human spermatogenesis by Renee H. Martin. According to Martin, meiotic studies on the pachytene stage of spermatogenesis have shown that infertile men have impaired chromosome synapsis, a significantly...

  • Y Chromosome Microdeletions and Prevalence in Infertile Tunisian Men.  // Fertility Weekly;4/24/2006, p2 

    The article discusses research being done on Y chromosome microdeletions and prevalence in infertile men in Tunisia. It references a study by L. Hadj-Kacem and colleagues published in the 2006 issue of "Archives of Andrology." The study finds that AZFc deletions are the most common Y chromosome...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics