Biopotentiation using Herbs: Novel Technique for Poor Bioavailable Drugs

Jhanwar, Bharat; Gupta, Somdutt
April 2014
International Journal of PharmTech Research;Apr2014, Vol. 6 Issue 2, p443
Academic Journal
Herbal source has been used by mankind recently at very high rate due to their lower risk benefit ratio in compared to the modern allopathic medicines. Concept of biopotentiation was not so novel it has been so far used in old times by ayurvedic peoples so called as Yogvahi. Bibliographic investigation revealed about such agents which cause potentiation of the pharmacologic effect even if administered at lower dose with active ingredient. Piperine, naringin, quercetin, glycyrrhizin, genistein, sinomenine, nitrile glycoside and cow urine distillate have capability to augment and enhance the bioavailability. A bioenhancers do not introduce its own therapeutic action with the actual active principle at the therapeutic dose used. Augmentation of bioefficacy reduce dose, toxicity and adverse effects so in return shorten the time and cost of treatment. These concept covers drug categories like antibiotics, antitubercular and anticancer and cardiovascular which are so potent in nature and require quite immediate effects. Aim of this review paper is to acknowledge the scientific society about various available natural bioavailability enhancers with their brief mechanism of action and pharmacotherapeutics application when supplemented with therapeutic ingredients. Future practices and studies are indeed for improvement in drug bioavailability exhibited particularly by natural compounds and find out some more novel agents from the wide array of unexploited herbs that have capability of biopotentiation or bioenhancing. Integration of aged and time trusted Ayurveda with modernized allopath always brings a new breakthrough in medicines.


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