TITLE

Evaluation of the Volatile Oil Composition and Antiproliferative Activity of Laurus nobilis L. (Lauraceae) on Breast Cancer Cell Line Models

AUTHOR(S)
Abu-Dahab, Rana; Kasabri, Violet; Afifi, Fatma Ulku
PUB. DATE
April 2014
SOURCE
Records of Natural Products;2014, Vol. 8 Issue 2, p136
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Volatile oil composition and antiproliferative activity of Laurus nobilis L. (Lauraceae) fruits and leaves grown in Jordan were investigated. GC-MS analysis of the essential oil of the fruits resulted in the identification of 45 components representing 99.7 % of the total oil content, while the leaf essential oil yielded 37 compounds representing 93.7% of the total oil content. Oxygenated monoterpene 1,8-cineole was the main component in the fruit and leaf oils. Using sulphorhodamine B assay; the crude ethanol fraction, among other solvent extracts, showed strong antiproliferative activity for both leaves and fruits, nevertheless, the fruits were more potent against both breast cancer cell models (MCF7 and T47D). At IC50 values; the mechanism of apoptosis was nevertheless different: where L. nobilis fruit proapoptotic efficacy was not regulated by either p53 or p21, L. nobilis leaf extract components enhanced the p53 levels substantially. In both extracts, apoptosis was not caspase-8 or Fas Ligand and sFas (Fas/APO-1) dependent. Our studies highlight L. nobilis as a potential natural agent for breast cancer therapy. Compared with non induced basal cells, both L. nobilis fruits and leaves induced a significant enrichment in the cytoplasmic mono- and oligonucleosomes after assumed induction of programmed MCF7 cell death.
ACCESSION #
95212867

 

Related Articles

  • Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of Cymbopogan citratus (lemon grass) against colorectal and breast carcinoma cell lines. Piaru, Suthagar Pillai; Perumal, Shanmugapriya; Cai, Lee Wei; Mahmud, Roziahanim; Majid, Amin Malik Shah Abdul; Ismail, Sabariah; Man, Che Nin // Journal of Essential Oil Research;Oct2012, Vol. 24 Issue 5, p453 

    The essential oil of Cymbopogan citratus (lemon grass) was isolated by steam distillation method and subjected to cytotoxicity activity using two different cell lines, human colon carcinoma (HCT-116), breast carcinoma cell lines (MCF-7) and anti-angiogenic activity. The cytotoxicity activity...

  • Methyl Angolensate from Callus of Indian Redwood Induces Cytotoxicity in Human Breast Cancer Cells. Chiruvella, Kishore K.; Panjamurthy, Kuppusamy; Choudhary, Bibha; Joy, Omana; Raghavan, Sathees C. // International Journal of Biomedical Science;2010, Vol. 6 Issue 3, p182 

    AIM: Natural products discovered from medicinal plants have played an important role in the treatment of cancer. Methyl angolensate (MA), a tetranortriterpenoid obtained from the root callus of Indian Redwood tree, Soymida febrifuga Roxb. (A.Juss) was tested for its anticancer properties on...

  • In vitro evaluation of apoptosis detection by Tc-tetrofosmin in MCF-7 breast cancer cell line. Tabar, E.; Lambrecht, F.; Gunduz, C.; Yucebas, M. // Journal of Radioanalytical & Nuclear Chemistry;Jun2011, Vol. 288 Issue 3, p839 

    Radiolabeled molecules have an important role to evaluate tumor characteristics such as aggressiveness, and to identify the effectiveness of cancer treatments such as chemotherapy and radiotherapy. Various radionuclide (F, Tc, I) labeled molecules can be used apoptosis detection by estimating...

  • TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines. Volate, Suresh; Hudson, Robert; Desuo Wang; Muga, Stephanie; Wargovich, Michael // Journal of Oncology;2009, p1 

    Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer cells lines. TJ-41 inhibited the proliferation of human breast cancer cell lines dose...

  • The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model. Ye, Tinghong; Xiong, Ying; Yan, Yupeng; Xia, Yong; Song, Xuejiao; Liu, Li; Li, Deliang; Wang, Ningyu; Zhang, Lidan; Zhu, Yongxia; Zeng, Jun; Wei, Yuquan; Yu, Luoting // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Breast carcinoma is the most common female cancer with considerable metastatic potential. Discovery of new therapeutic approaches for treatment of metastatic breast cancer is still needed. Here, we reported our finding with niclosamide, an FDA approved anthelmintic drug. The potency of...

  • Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Xue Zhu; Ke Wang; Kai Zhang; Ting Zhang; Yongxiang Yin; Fei Xu // International Journal of Molecular Sciences;Nov2016, Vol. 17 Issue 11, p1903 

    Background: Due to the aggressive clinical behavior, poor outcome, and lack of effective specific targeted therapies, triple-negative breast cancer (TNBC) has currently been recognized as one of the most malignant types of tumors. In the present study, we investigated the cytotoxic effect of...

  • Oncolytic Effect of Newcastle Disease Virus AF2240 Strain on the MCF-7 Breast Cancer Cell Line. Othman, Fauziah; Ideris, Aini; Motalleb, Gholamreza; Bt. Eshak, Zulkapli; Rahmat, Asmah // Yakhteh Medical Journal;Spring2010, Vol. 12 Issue 1, p17 

    Objective: This study was carried out to investigate the oncolytic effect of the Newcastle disease virus (NDV) strain AF2240 on the MCF-7 breast cancer cell line. Materials and Methods: The NDV-AF2240 was propagated in 11 days old embryonated chicken eggs for 72 hours. The virus in the allantoic...

  • miR-101 Promotes Breast Cancer Cell Apoptosis by Targeting Janus Kinase 2. Wang, Lu; Li, Linqiang; Guo, Rui; Li, Xuelian; Lu, Ying; Guan, Xiaoxiang; Gitau, Samuel Chege; Wang, Leimin; Xu, Chaoqian; Yang, Baofeng; Shan, Hongli // Cellular Physiology & Biochemistry (Karger AG);Aug2014, Vol. 34 Issue 2, p413 

    Aims: microRNA-101 (miR-101) is down-regulated in several cancers. In this study, we explored the effects of dysregulated miR-101 on breast cancer cells and the underlying mechanisms. Methods: miR-101 level was quantified by real-time RT-PCR. Cell viability was analyzed by MTT assay. Apoptosis...

  • TNF-a Gene Knockout in Triple Negative Breast Cancer Cell Line Induces Apoptosis. Pileczki, Valentina; Braicu, Cornelia; Gherman, Claudia D.; Berindan-Neagoe, Ioana // International Journal of Molecular Sciences;Jan2013, Vol. 14 Issue 1, p411 

    Tumor necrosis factor alpha (TNF-a) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there is significant interest in understanding the molecular signaling pathways that connect TNF-a with the survival of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics