TITLE

EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF Euphorbia cotinifolia LINN. LEAF EXTRACTS

AUTHOR(S)
JAYALAKSHMI, B.; RAVEESHA, K. A.; AMRUTHESH, K. N.
PUB. DATE
January 2014
SOURCE
Chemical Industry & Chemical Engineering Quarterly;2014, Vol. 20 Issue 1, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Antibacterial activity of aqueous and solvent extracts of Euphorbia cotinifolia leaves was tested against some human pathogenic bacteria, viz. Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Enterobacter aerogenes and Staphylococcus aureus by agar cup diffusion and broth microdilution methods. Antioxidant properties were evaluated for different solvent extracts by di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH), nitric oxide (NO) and hydrogen peroxide methods and IC50 values were calculated and compared with the standard ascorbic acid and butylated hydroxyanisole. Among the aqueous and organic solvent extracts, methanol and ethyl acetate showed significant activity against B. subtilis and E. aerogenes, which recorded a maximum inhibition zone of 17.25 mm. Minimum inhibitory concentrations of methanol and ethyl acetate extracts for different bacteria ranged from 0.3-1.25 mg/mL. In DPPH method, IC50 values of chloroform, petroleum ether, ethyl acetate and methanol were found to be 15, 17, 18 and 19 mg/mL, respectively, lesser than the standard, ascorbic acid (25 mg/mL). Phytochemical analysis of aqueous, ethyl acetate and methanol extract showed the presence of flavonoids, terpenoids, tannins and steroids. Further work is in progress to isolate the active compound(s).
ACCESSION #
95212842

 

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