Vaishnavi, T. L.; Battu, Sowjanya; Rao, V. Uma Maheshwara
January 2014
International Journal of Pharmacy;2014, Vol. 4 Issue 1, p289
Academic Journal
In the present study, an attempt was made to formulate, comparatively evaluate and optimize multiple lipid drug carriers of valsartan for oral controlled release. Two lipid drug delivery systems i.e. Niosomes and Liposomes were studied for the delivery of the anti-hypertensive drug valsartan. They were formulated as suspensions. Ether injection and rotary evaporator method were chosen for the formulation of physically and chemically stable niosomes and liposomes of valsartan.In-vitro evaluation studies for the prepared multiple drug delivery carriers of valsartan were performed. The in-vitro evaluation studies performed were evaluation for physical appearance, particle size by scanning electron microscopy (SEM), drug content , entrapment efficiency and in-vitro drug release. Optimization of the best lipid drug delivery system and the best method of preparation was done based on the results of In-Vitro drug release and entrapment efficiency values. Finally, an attempt was made to improve the bioavailabilty of the administered drug, reduce side effects and improve patient compliance by optimizing the best formulation through lipid drug delivery technology.


Related Articles

  • Triggered Activation and Release of Liposomal Prodrugs and Drugs in Cancer Tissue by Secretory Phospholipase A2. Andresen, Thomas L.; Jensen, Simon S.; Kaasgaard, Thomas; Jørgensen, Kent // Current Drug Delivery;Dec2005, Vol. 2 Issue 4, p353 

    The selectivity of anticancer drugs in targeting the tumour tissue presents a major problem in cancer treatment. In this article we review a new generation of smart liposomal nanocarriers that can be used for enhanced anticancer drug and prodrug delivery to tumours. The liposomes are engineered...

  • Characterization and Stability of Nanostructured Lipid Carriers as Drug Delivery System. Abbasalipourkabir, R.; Salehzadeh, A.; Abdullah, R. // Pakistan Journal of Biological Sciences;2/1/2012, Vol. 15 Issue 3, p141 

    Recently more focus has been put to be the development of innovation drug-delivery systems that includes polymer nanoparticles, emulsions and liposomes and solid lipid nanoparticles (SLNs). The SLNs have been proposed to be an alternative colloidal drug delivery system. The aim of this study was...

  • Niosomes: The ultimate drug carrier. Subodh, Dubey; Amit, Jain; Mehta, S. C.; Gupta, Pavan; Jain, Sandeep; Sahu, Jagdish // Drug Invention Today;Jan2010, Vol. 2 Issue 1, p72 

    Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The method of preparation of niosome is based on liposome...

  • Multifunctional Dendritic Drug Delivery Systems: Design, Synthesis, Controlled and Triggered Release. Paleos, Constantinos M.; Tsiourvas, Dimitris; Sideratou, Zili; Tziveleka, Leto // Current Topics in Medicinal Chemistry;Sep2008, Vol. 8 Issue 14, p1204 

    This review describes the strategy for the development of multifunctional dendrimeric and hyperbranched polymers, collectively named dendritic polymers, aiming at their application as drug and gene delivery systems. Employing well-characterized and mainly commercially available dendritic...

  • Self-organized nanoparticles based on drug-interpolyelectrolyte complexes as drug carriers. Palena, M.; Manzo, R.; Jimenez-Kairuz, A. // Journal of Nanoparticle Research;Jun2012, Vol. 14 Issue 6, p1 

    Potential applications in drug delivery from nanostructures composed of two oppositely charged polymethacrylates, eudragit L100 (EL) and eudragit EPO (EE), loaded with three model basic drugs (D), atenolol, propranolol, and metroclopramide were evaluated. The self-organized nanoparticles based...

  • COLON SPECIFIC DRUG DELIVERY SYSTEMS: A REVIEW ON PRIMARY AND NOVEL APPROACHES. Challa, Threveen; Vynala, Vinay; Allam, Krishna Vamshi // International Journal of Pharmaceutical Sciences Review & Resear;Mar/Apr2011, Vol. 7 Issue 2, p171 

    Colon specific drug delivery has gained increased importance not just for delivery of the drugs in the treatment associated with the colon, but also as a potential site for the systemic delivery of therapeutic peptides and proteins. To achieve successful colon targeted drug delivery, a drug need...

  • Simultaneous spectrophotometric estimation of tamsulosin and tolterodine in its pharmaceutical dosage form. Nanda, Ravindra Kumar; Gaikwad, Jagdish; Prakash, Anand // Journal of Pharmacy Research;Aug2009, Vol. 2 Issue 8, p1266 

    Two accurate and precise methods were developed for the estimation of Tamsulosin and Tolterodine in its pharmaceutical dosage form. First method is based on the simultaneous equations and wavelengths selected for analysis were 225.5 nm (?max of Tamsulosin) and 284.0 nm (?max of Tolterodine)...

  • PRONIOSOMES: AN EMERGENT DRUG DELIVERY SYSTEM. Aparna, Adella; Renuka, P.; Adukondalu, D. // Pharma Science Monitor;Jul-Sep2014, Vol. 5 Issue 3, p47 

    Controlled release drug products are often formulated to permit the establishment and maintenance of drug concentration at target site for longer interval of time. One such technique of drug targeting is 'niosome'. In order to minimize the problems associated with niosome physical stability such...

  • In-vitro Modeling of the Release Kinetics of Micron and Nano-Sized Polymer Drug Carriers. Razavilar, Negin; Choi, Phillip // International Journal of Drug Delivery;2013, Vol. 5 Issue 4, p362 

    This article reviews in-vitro modeling of the release kinetics of hydrophobic drugs encapsulated by polymeric materials. Major continuum models along with their assumptions and limitations for micron-sized systems will be considered. The dependence on the swelling and degradation for such...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics