Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients

Khlifi, Rim; Chakroun, Amine; Hamza-Chaffai, Amel; Rebai, Ahmed
April 2014
Molecular Biology Reports;Apr2014, Vol. 41 Issue 4, p2591
Academic Journal
The purpose of this study was to investigate the relationship between head and neck cancer (HNC) and environmental agents and polymorphisms in CYP1A1, CYP2D6, NAT1 and NAT2 metabolic enzymes genes. To the best of our knowledge, this is the first report on polymorphisms in CYP1A1 6310C>T, CYP2D6 Arg365His, NAT1 52936A>T and NAT2 Arg268Lys ( NAT2*12A) genes and susceptibility to HNC in Tunisian population. We study the prevalence of these polymorphisms in 169 patients with HNC and 261 control subjects using polymerase chain reaction based methods in a Tunisian population. We detected an association between HNC and CYP1A1 6310C>T (TT) and CYP2D6 Arg365His (His/His) variant carriers (OR 1.75, P = 0.008 and OR 1.66, P = 0.016, respectively). No association was found between the polymorphisms genotypes of NAT1 52936T>A and NAT2 Arg268Lys and risk of HNC. An association between HNC and CYP1A1 (TT) genotype was found among patients with smoking ( P = 0.011) and drinking habit ( P = 0.009). The combinations of NAT1 (AT or AA) and NAT2 (AA) at-risk genotypes increased HNC risk (OR 4.23, P = 0.005 and OR 3.60, P = 0.048, respectively). However, the combinations of CYP1A1 (AA) and CYP2D6 (CC) genotypes decreased risk of HNC (OR 0.20; P = 0.006). Genetic polymorphisms in CYP1A1 and CYP2D6 may significantly associate with HNC in the Tunisian population. The results of this study suggest a possible gene-environment interaction for certain carcinogen metabolizing enzymes, but larger studies that fully evaluate the interaction are needed.


Related Articles

  • N-acetyltransferase 2 single-nucleotide polymorphisms and risk of gastric carcinoma. Ladero, José M.; Agúndez, José A. G.; Olivera, Manuela; Lozano, Luis; Rodríguez-Lescure, Alvaro; Diaz-Rubio, Manuel; Benítez, Julio // European Journal of Clinical Pharmacology;May2002, Vol. 58 Issue 2, p115 

    Objective. To explore whether an association exists between the NAT2 genotype and the risk of developing gastric cancer. Methods. Ninety-nine patients with gastric adenocarcinoma and 258 healthy subjects were analysed for single-nucleotide polymorphisms at the NAT2 gene locus, which give rise to...

  • Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS) – novel predictors for response and survival in gastric cancer patients. Goekkurt, E.; Hoehn, S.; Wolschke, C.; Wittmer, C.; Stueber, C.; Hossfeld, D. K.; Stoehlmacher, J. // British Journal of Cancer;1/30/2006, Vol. 94 Issue 2, p281 

    To evaluate the predictive value of a panel of gene polymorphisms involved in metabolism of 5-FU and cisplatin on clinical outcome in advanced gastric cancer patients. A total of 52 patients were enrolled in this study. DNA was extracted from paraffin-embedded tumour specimen. Genotypes were...

  • The G Protein �3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype. C.K. Naber; R. Erbel; W. Siffert // Current Genomics;May2003, Vol. 4 Issue 4, p337 

    Using a classical candidate gene approach, we have described a common C825T polymorphism in the gene GNB3, encoding the ubiquitously expressed �3 subunit of heterotrimeric G proteins. The 825T allele causes alternative splicing of the gene and the generation of a truncated but functionally...

  • An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients. Crea, F.; Fornaro, L.; Paolicchi, E.; Masi, G.; Frumento, P.; Loupakis, F.; Salvatore, L.; Cremolini, C.; Schirripa, M.; Graziano, F.; Ronzoni, M.; Ricci, V.; Farrar, W. L.; Falcone, A.; Danesi, R. // Annals of Oncology;May2012, Vol. 23 Issue 5, p1207 

    Background: Despite therapeutic innovations, metastatic colorectal cancer (mCRC) is still characterized by poor prognosis and few molecular markers predict the risk of progression. Polycomb group genes (PcGs) are epigenetic modifiers involved in tumor suppressor gene silencing. PcG member EZH2...

  • p53 intron 7 polymorphisms in urinary bladder cancer patients and controls. Berggren, Petra; Hemminki, Kari; Steineck, Gunnar // Mutagenesis;Jan2000, Vol. 15 Issue 1, p57 

    A C→T polymorphism in intron 7 of the human tumour suppressor gene p53 was studied in 159 urinary bladder cancer patients and 171 non-cancer controls. The polymorphism was found in 15% of both patients and controls, suggesting that it has no relevance in urinary bladder cancer...

  • Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. Maier, C.; Haeusler, J.; Herkommer, K.; Vesovic, Z.; Hoegel, J.; Vogel, W.; Paiss, T. // British Journal of Cancer;3/28/2005, Vol. 92 Issue 6, p1159 

    To date, germline mutations have been found in three candidate genes for hereditary prostate cancer: ELAC2 at 17p11, RNASEL at 1q25 and MSR1 at 8p22. RNASEL, encoding the 2',5'-oligoadenylate-dependant RNase L, seems to have rare mutations in different ethnicities, such as M1I in Afro-Americans,...

  • stepwiseCM: An R Package for Stepwise Classification of Cancer Samples Using Multiple Heterogeneous Data Sets. Obulkasim, Askar; van de Wiel, Mark A. // Cancer Informatics;2014, Issue 13, p1 

    This paper presents the R/Bioconductor package stepwiseCM, which classifies cancer samples using two heterogeneous data sets in an efficient way. The algorithm is able to capture the distinct classification power of two given data types without actually combining them. This package suits for...

  • Clinical Impact of MMP and TIMP Gene Polymorphisms in Gastric Cancer. Alakus, Hakan; Afriani, Noor; Warnecke-Eberz, Ute; Bollschweiler, Elfriede; Fetzner, Ulrich; Drebber, Uta; Metzger, Ralf; Hölscher, Arnulf; Mönig, Stefan // World Journal of Surgery;Dec2010, Vol. 34 Issue 12, p2853 

    Background: Recent studies suggest that single-nucleotide polymorphisms (SNPs) within matrix metalloproteinase (MMP) genes and genes of tissue inhibitors of metalloproteinases (TIMPs) have an impact on the expression of these genes and on the prognosis for gastric cancer. Methods: Genomic DNA...

  • Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. Sreeja, Leelakumari; Syamala, Volga S.; Syamala, Vani; Hariharan, Sreedharan; Raveendran, Praveenkumar B.; Vijayalekshmi, R. V.; Madhavan, Jayaprakash; Ankathil, Ravindran // Journal of Cancer Research & Clinical Oncology;Jun2008, Vol. 134 Issue 6, p645 

    Inter individual variation in lung cancer susceptibility may be modulated in part through genetic polymorphisms in the DNA repair genes, especially the genes involved in the Base Excision Repair (BER) and nucleotide excision repair (NER) pathway. Two of the genetic polymorphisms, XRCC1Arg399Gln...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics