Hemoglobin as a chariot for NO bioactivity

Lane, Paul; Gross, Steven
July 2002
Nature Medicine;Jul2002, Vol. 8 Issue 7, p657
Academic Journal
Focuses on a study that suggests that red blood cells distribute nitric oxide (NO) bioactivity. Role of NO as a potent vasodilator; Benefits of the data in analyzing the problems with the use of hemoglobin as a blood substitute.


Related Articles

  • On the impact of NO–globin interactions in the cardiovascular system Gödecke, Axel // Cardiovascular Research;Feb2006, Vol. 69 Issue 2, p309 

    Abstract: During the last years, many reports have provided evidence that the concept of a simple, diffusion-controlled action of NO must be extended by the existence of storage and long-distance transport forms of NO suitable to extend the half-life of the NO radical. In addition, hemoglobin...

  • Nitric oxide in the human respiratory cycle. McMahon, Timothy J.; Moon, Richard E.; Luschinger, Ben P.; Carraway, Martha S.; Stone, Anne E.; Stolp, Bryant W.; Gow, Andrew J.; Pawloski, John R.; Watke, Paula; Singel, David J.; Piantadosi, Claude A.; Stamler, Jonathan S. // Nature Medicine;Jul2002, Vol. 8 Issue 7, p711 

    Interactions of nitric oxide (NO) with hemoglobin (Hb) could regulate the uptake and delivery of oxygen (O2) by subserving the classical physiological responses of hypoxic vasodilation and hyperoxic vasconstriction in the human respiratory cycle. Here we show that in in vitro and ex vivo systems...

  • 2001 Lemieux Award Lecture Organic chemistry and hemoglobin: Benefits from controlled alteration. Kluger, Ronald // Canadian Journal of Chemistry;Mar2002, Vol. 80 Issue 3, p217 

    Hemoglobin carries oxygen in circulation within red cells but does not function outside the cells because it fails not only to release oxygen but also dissociates into dimers that make up the tetrameric protein. Bifunctional anionic acylating agents that contain a structurally rigid bridge...

  • Cardioprotective role of S-nitrosylated hemoglobin from rbc. Piantadosi, Claude A. // Journal of Clinical Investigation;Dec2016, Vol. 126 Issue 12, p4402 

    Nitric oxide (NO) is a potent mediator of blood vessel dilation and is released by several cell sources. Red blood cells (rbc) release NO when hemoglobin that has been S-nitrosylated at Cys93 of the β-chain (βCys93) transitions from the oxygenated form to the deoxygenated form. This...

  • Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme. Milani, Mario; Pesce, Alessandra; Ouellet, Vannick; Ascenzi, Paolo; Guertin, Michel; Bolognesi, Martino // EMBO Journal;8/1/2001, Vol. 20 Issue 15, p3902 

    Macrophage-generated oxygen- and nitrogen-reactive species control the development of Mycobacterium tuberculosis infection in the host. Mycobacterium tuberculosis 'truncated hemoglobin' N (trHbN) has been related to nitric oxide (NO) detoxification, in response to macrophage nitrosative stress,...

  • Effects of spermine NONOate and ATP on the thermal stability of hemoglobin. Bassam, Rasha; Hescheler, Juergen; Temiz-Artmann, Ayseguel; Artmann, Gerhard M.; Digel, Ilya // BMC Biophysics;2012, Vol. 5 Issue 1, p16 

    Background: Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study...

  • Effect of Na-,Fe-,Co-,Cu-polygalacturonate on hemopoietic function in laboratory animals. A. Vyshtakalyuk; A. Karaseva; V. Karlin; S. Minzanova; V. Mironov; A. Konovalov; I. Tikhonova // Bulletin of Experimental Biology & Medicine;Jan2007, Vol. 143 Issue 1, p40 

    Abstract  The effects of water-soluble Na-,Fe-,Co-,Cu-polygalacturonate on hemopoiesis were studied in laboratory animals of various species, age, and functional groups. The compound had a strong positive effect on hemopoiesis, which manifested in an increase in hemoglobin concentration...

  • Limitation of muscle deoxygenation in the triceps during incremental arm cranking in women. Muraki, Satoshi; Tsunawake, Noriaki; Yamasaki, Masahiro // European Journal of Applied Physiology;Mar2004, Vol. 91 Issue 2/3, p246 

    The present study investigated the difference in oxygen kinetics in the exercising muscle between arm cranking and leg cycling in women. Twenty-seven females completed incremental arm cranking and leg cycling tests on separate days. During each exercise, spatially resolved near-infrared...

  • Hemoglobins: Diversity of structures and functions. Kosmachevskaya, O. V.; Topunov, A. F. // Applied Biochemistry & Microbiology;Nov2009, Vol. 45 Issue 6, p563 

    This review briefs the modern concepts of the diversity of hemoglobin functions. The hemoglobins discovered in the representatives of all kingdoms of living nature are described. Specific structural features of various groups of these proteins, including flavohemoglobins and truncated...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics