TITLE

Cerebral MR Spectroscopy In Neurologically Asymptomatic Hiv-Infected Patients

AUTHOR(S)
Tarasów, E.; Wiercińska-Drapało, A.; Kubas, B.; Dzienis, W.; Orzechowska-Bobkiewicz, A.; Prokopowicz, D.; Walecki, J.
PUB. DATE
March 2003
SOURCE
Acta Radiologica;Mar2003, Vol. 44 Issue 2, p206
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Purpose: To detect early metabolic changes in the brain of neurologically asymptomatic HIV-infected patients with normal MR imaging and to find the correlation between 1H MR results and immune status. Material and Methods: Twenty neurologically asymptomatic HIV seropositive patients underwent MR imaging and single-voxel 1H MR spectroscopy (MRS) using a PRESS sequence. For all patients, the signals from N-acetyl-aspartate (NAA), choline-containing compounds (Cho), creatine-phosphocreatine (Cr) and myoinositol (mI) were compared with 32 healthy volunteers as metabolite ratios and metabolite areas to non-suppressed water area ratios. Results: In HIV patients, the NAA/Cho ratio was significantly lower ( p < 0.01), but there were no changes in NAA/Cr ratio. A statistically significant reduction in NAA/H2 O and Cr/H2 O (both p < 0.05) was observed. For the immune status there was a statistically significant correlation (r= 0.47, p <0.05) between CD4 counts and NAA/H2 O ratio. A significant increase in Cho/Cr ( p <0.001) and mI/Cr ( p <0.01) ratios in HIV patients was found, but Cho/H2 O and mI/H2 O concentrations were non-significantly increased. Conclusion: These results indicate that neuronal loss and gliosis in HIV-infected patients may be associated with impairment of energy metabolism. The spectral changes found suggest that 1H MRS can be used for early detection of brain damage induced by HIV.
ACCESSION #
9510398

 

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