Cerebral MR Spectroscopy In Neurologically Asymptomatic Hiv-Infected Patients

Tarasów, E.; Wiercińska-Drapało, A.; Kubas, B.; Dzienis, W.; Orzechowska-Bobkiewicz, A.; Prokopowicz, D.; Walecki, J.
March 2003
Acta Radiologica;Mar2003, Vol. 44 Issue 2, p206
Academic Journal
Abstract Purpose: To detect early metabolic changes in the brain of neurologically asymptomatic HIV-infected patients with normal MR imaging and to find the correlation between 1H MR results and immune status. Material and Methods: Twenty neurologically asymptomatic HIV seropositive patients underwent MR imaging and single-voxel 1H MR spectroscopy (MRS) using a PRESS sequence. For all patients, the signals from N-acetyl-aspartate (NAA), choline-containing compounds (Cho), creatine-phosphocreatine (Cr) and myoinositol (mI) were compared with 32 healthy volunteers as metabolite ratios and metabolite areas to non-suppressed water area ratios. Results: In HIV patients, the NAA/Cho ratio was significantly lower ( p < 0.01), but there were no changes in NAA/Cr ratio. A statistically significant reduction in NAA/H2 O and Cr/H2 O (both p < 0.05) was observed. For the immune status there was a statistically significant correlation (r= 0.47, p <0.05) between CD4 counts and NAA/H2 O ratio. A significant increase in Cho/Cr ( p <0.001) and mI/Cr ( p <0.01) ratios in HIV patients was found, but Cho/H2 O and mI/H2 O concentrations were non-significantly increased. Conclusion: These results indicate that neuronal loss and gliosis in HIV-infected patients may be associated with impairment of energy metabolism. The spectral changes found suggest that 1H MRS can be used for early detection of brain damage induced by HIV.


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