Seroprevalence of hepatitis B virus infection among antenatal clinic attendees at a tertiary hospital in Dar es Salaam, Tanzania

January 2014
Tanzania Journal of Health Research;Jan2014, Vol. 16 Issue 1, p1
Academic Journal
Hepatitis B virus (HBV) infection is a serious public health problem in sub-Saharan Africa. The risk of vertical transmission increases if the mother is hepatitis B surface antigen (HBsAg) positive and more so when she is also hepatitis B envelope antigen (HBeAg) positive. Since 2000, the World Health Organization recommends screening of pregnant women for HBV infection. However, this is not currently practiced in Tanzania. The objective of this study was to determine seroprevalence and associated factors of HBV infection among pregnant women attending antenatal clinic at the Muhimbili National Hospital, in Dar es Salaam, Tanzania. This cross-sectional study was conducted from August-September 2010. Data on sociodemographic characteristics, obstetric and risk factors such as history of blood transfusion, and risky sexual practices was collected. Blood samples were tested for HBsAg, HBeAg, antibodies to HBsAg (Anti- HBs), IgM antibodies to hepatitis B core antigen (Anti-HBc) and anti-HIV antibodies. A total of 310 pregnant women (28.5±5.4 years) were enrolled in the study. Thirty-one percent (96) of the women were primigravidae. Most of studied women were of low educational status and married. The seroprevalence of HBsAg was 3.9% (12/310) and none had detectable anti-HBs. None had IgM HBcAb, thus excluding acute HBV infection. All women tested negative for HBeAg. The overall seroprevalence of HIV infection was 9.7%. Three of 12 (25%) women had HBV-HIV co-infection. None of the assessed associated factors were significantly related to HBV infection. In conclusion, the seroprevalence of HBsAg among women attending antenatal care at Muhimbili National Hospital is moderate. It is recommended to introduce routine antenatal screening for HBV and "at birth dose" vaccination to new born babies of mothers found to be HBsAg positive.


Related Articles

  • Hepatitis A Immunity in the District of Aveiro (Portugal): An Eleven-Year Surveillance Study (2002-2012). Pereira, Sara; Linhares, Inês; Neves, António Ferreira; Almeida, Adelaide // Viruses (1999-4915);Mar2014, Vol. 6 Issue 3, p1336 

    Hepatitis A is a common viral liver disease and brings serious health and economic problems as its epidemiologic pattern changes over time. National serosurveys from developed countries have indicated a decline in HAV (hepatitis A virus) seroprevalence over time due to the improvement of...

  • Seroprevalence of Co-infection of Hepatitis B and Hepatitis C Genotypes among Adult Female Population of Karachi, Pakistan. Hakim, Shazia Tabassum; Noorali, Samina; Ashby, Meaghen; Bagasra, Anisah; Kazmi, Shahana U.; Bagasra, Omar // British Journal of Medical Practitioners;Sep2010, Vol. 3 Issue 3, p11 

    Background: Both Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are aetiological agents of acute and chronic liver disease existing throughout the world. The high genetic variability of HBV and HCV genome is reflected by eight genotypes (A to H) and six genotypes (1 to 6), respectively....

  • Hepatitis B Virus Infection in Iran: A Systematic Review. Alavian, Seyed Moayed; Hajarizadeh, Behzad; Ahmadzad-Asl, Masoud; Kabir, Ali; Bagheri-Lankarani, Kamran // Hepatitis Monthly;Autumn2008, Vol. 8 Issue 4, p281 

    Background and Aims: Hepatitis B virus (HBV) infection is a worldwide problem. It is estimated that 400 million people are suffering from this infection. We conducted a systematic review to put all evidence on HBV infection in I.R. Iran and to make an accurate estimate of HBV infection...

  • Serotypes and Genotypes of the Hepatitis B Virus in Latin America. Ribas-Aparicio, Rosa María; Valdez-Salazar, Hilda-Alicia; Aparicio-Ozores, Gerardo; Ruiz-Tachiquín, Martha-Eugenia // Annual Review & Research in Biology;2014, Vol. 4 Issue 8, p1307 

    The World Health Organization has estimated that 2 billion persons are infected with the hepatitis B virus (HBV) with 360 million persons chronically affected. Worldwide, HBV is the causal agent of cirrhosis (30%) and hepatocellular carcinoma (50%). Methods of transmission for HBV are prenatal,...

  • Sero-prevalence of Hepatitis B surface antigen amongst pregnant women attending an antenatal clinic, Volta region, Ghana. Luuse, Arnold; Dassah, Sylvester; Lokpo, Sylvester; Ameke, Louise; Noagbe, Mark; Adatara, Peter; Hagan, Oheneba; Binka, Fred // Journal of Public Health in Africa;2016, Vol. 7 Issue 2, p81 

    Hepatitis B virus (HBV) infection remains a global challenge, although there is currently a safe and effective vaccine available. HBV prevalence in Ghana is not well documented, but vary regionally from 4.8% to 12.3% in the general population, 10.8% to 12.7% in blood donors and about 10.6% in...

  • Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection.  // BMC Gastroenterology;2012, Vol. 12 Issue 1, p43 

    The article discusses a study conducted to know the significance of T (Treg) cells and interlukin-17-producing T help cells (Th17) balance in the development of acute and chronic hepatitis B virus (HBV) infection. IT has been informed that the study results found that Th17 cells are involved in...

  • Tularemia transmission to humans: a multifaceted surveillance approach. Akhvlediani, N.; Burjanadze, I.; Baliashvili, D.; Tushishvili, T.; Broladze, M.; Navdarashvili, A.; Dolbadze, S.; Chitadze, N.; Topuridze, M.; Imnadze, P.; Kazakhashvili, N.; Tsertsvadze, T.; Kuchuloria, T.; Akhvlediani, T.; McNutt, L.-A.; Chanturia, G. // Epidemiology & Infection;Dec2018, Vol. 146 Issue 16, p2139 

    Tularemia has sustained seroprevalence in Eurasia, with estimates as high as 15% in endemic regions. The purpose of this report is to characterise the current epidemiology of Francisella tularensis subspecies holarctica in Georgia. Three surveillance activities are summarised: (1) acute...

  • Seroprevalence of hepatitis B virus markers in individuals for physical examination in West China Hospital, China. WANG, Y.-B.; CHEN, E.-Q.; CUI, Y.-L.; ZENG, L.; WANG, Y.-J.; TANG, H. // European Review for Medical & Pharmacological Sciences;2011, Vol. 15 Issue 6, p592 

    Background: Hepatitis B virus (HBV) is the major cause of chronic hepatitis,cirrhosis, and hepatocellular carcinoma. The global epidemiological scenario of HBV infection has been changing rapidly over the last two decades due to an effective immunization programme initiated by the World Health...

  • Hepatitis B seroprevalence in persons attending youth clinics in Stockholm, Sweden in 2008. Stenkvist, J.; Lidbrink, P.; Olofsson, I.; von Sydow, M.; Lindh, G. // International Journal of STD & AIDS;Nov2012, Vol. 23 Issue 11, p767 

    Sweden is a low endemicity country for hepatitis B virus (HBV). The previously reported prevalence of chronic HBV is ,1% and of overall markers ,5%. HBV is not included in the universal childhood vaccination programme. Instead, selected high-risk groups are targeted. Our aim was to examine the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics