Prostat iğne biyopsisi ve radikal prostatektomi materyallerinde gleason skorlarının karşılaştırılması

Kürşat Bozkurt, Kemal; Kızmaz, Mustafa; İnan Mamak, Gülsün; Korkmaz, İsmail; Bircan, Sema
June 2013
Medical Journal of Suleyman Demirel University;2013, Vol. 20 Issue 3, p93
Academic Journal
Aim: Gleason score (GS) is an important prognostic marker for prostate cancer and it is strongly correlated with stage and prognosis. However, needle biopsy (NB) GS is not always consistent with that of radical prostatectomy (RP) specimens. In this study, the correlation of GSs of NB and RP specimens will be examined. Materials and Methods: Study population comprised of 51 patients who had diagnosed as adenocarcinoma by prostate NB and underwent RP operation. The GSs of both specimens were compared and their correlation was investigated. In addition, the effect of blood prostate-specific antigen (PSA) levels and number of tumor positive quadrants in NBs on the correlation was also examined. Results: Gleason scores of NBs were 6, 7 and 9 in 43 (84.3%), 7 (13.7%) and I (2%) patients respectively. Exact correlation existed between GSs of NB and RP specimens for 35 (68.6%) cases. Positive predictive values for biopsy GSs 6 and 7 were 65.1% and 100%, respectively. Fifteen (29.4%) biopsies were undergraded and 1 (2%) was overgraded. Blood PSA levels and number of tumor positive quadrants in prostate NBs did not affect GS correlation (p>0.05). Conclusion: Gleason scoring system is an important parameter on determining the treatment and prognosis in prostate cancer. Thereby, it is important to provide a correlation between GSs of prostate NBs and RP specimens for the treatment.


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