Lipid Peroxidation and State of the Erythron in Newborn Rats under Normal Conditions and Impairment of Sensorimotor Reflexes

Kolesnikova, L.; Popova, A.; Gornostaeva, A.; Sinitskii, A.; Solomatova, T.
February 2014
Bulletin of Experimental Biology & Medicine;Feb2014, Vol. 156 Issue 4, p445
Academic Journal
Specimens with a stereotypic sensorimotor deficit were revealed among newborn rats due to abnormalities in prenatal ontogeny and birth stress. Genetically determined differences in the total lipid content of blood plasma were found in Wistar and August rat pups. Hence, LPO processes were shown to differ in these animals. August rats with intense lipid metabolism were characterized by higher activity of LPO in comparison with Wistar rats. The increase in LPO was associated with a relatively low activity of antioxidant enzymes. Impairment of sensorimotor reflexes in newborn Wistar and August rats was accompanied by suppression of the erythron and activation of extravascular hemolysis.


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