TITLE

Antioxidants to abrogate free radicals: new insights to challenge currently held beliefs

AUTHOR(S)
Schloss, Janet M.; Vitetta, Luis
PUB. DATE
January 2014
SOURCE
Australian Journal of Herbal Medicine;2014, Vol. 26 Issue 1, p4
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Compounds found in foods, nutrients and herbs commonly defined as antioxidants have been posited to neutralise free radicals produced by cellular oxidation reactions in the hope of ameliorating symptoms of chronic diseases. It has been reported that the body can function effectively with low levels of free radicals but if there is an overload of reactive oxygen species (ROS) and/ or reactive nitrogen species (RNS) that there is an increased risk for heart disease, cancer, and other chronic diseases. However, physiologically, the idea of neutralising a free radical with an antioxidant is very much a chimera. Five decades of in vitro and in vivo investigations on antioxidants and free radicals with no proven mechanistic understanding has confused researchers, antioxidant compound manufacturers and the public. This commentary advances a biochemical understanding as to the antioxidant / free radical connection that runs counter to decades of research dogma. The notion that an over production of free radicals such as superoxide anions and hydrogen peroxide are deleterious to health by causing cellular damage is not proven. The increased risk for chronic diseases and the aging process due to an overload of intracellular free radicals is untenable and challenged. These compounds are required for normal cellular function. Furthermore, as an example, we cite vitamin C, the bastion of the antioxidant library of molecules, as anything but an antioxidant in vivo. Vitamin C is an essential co-enzyme and plays an oxido-reductase role in the hydroxylations of, for example, pro-collagen.
ACCESSION #
94849884

 

Related Articles

  • Free Radicals and Antioxidants: A Review. Mathew, Blessy Baby; Tiwari, Archana; Jatawa, Suresh Kumar // Journal of Pharmacy Research;Dec2011, Vol. 4 Issue 12, p4340 

    Oxidation is a significant biological process for energy production in the body. One of the crucial problem is the tendency of the oxygen molecule to create free radicals. These radicals are by-products of the natural metabolism, and their constant exposure can give rise to oxidative stress...

  • Protective Effect of Natural Antioxidants on Heart Against Ischemia-Reperfusion Damage. Yan Zhao; Baolu Zhao // Current Pharmaceutical Biotechnology;Dec2010, Vol. 11 Issue 8, p868 

    No abstract available.

  • Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Yu-Jie Zhang; Ren-You Gan; Sha Li; Yue Zhou; An-Na Li; Dong-Ping Xu; Hua-Bin Li // Molecules;Dec2015, Vol. 20 Issue 12, p21138 

    Overproduction of oxidants (reactive oxygen species and reactive nitrogen species) in the human body is responsible for the pathogenesis of some diseases. The scavenging of these oxidants is thought to be an effective measure to depress the level of oxidative stress of organisms. It has been...

  • Resources and Biological Activities of Natural Polyphenols. An-Na Li; Sha Li; Yu-Jie Zhang; Xiang-Rong Xu; Yu-Ming Chen; Hua-Bin Li // Nutrients;2014, Vol. 6 Issue 12, p6020 

    The oxidative stress imposed by reactive oxygen species (ROS) plays an important role in many chronic and degenerative diseases. As an important category of phytochemicals, phenolic compounds universally exist in plants, and have been considered to have high antioxidant ability and free radical...

  • ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF LEUCAS ASPERA L. Borah, Archana; Singh Yadav, Raj Narayan; Gopalan Unni, Bala // International Journal of Pharmaceutical Sciences Review & Resear;Jul/Aug2011, Vol. 9 Issue 2, p46 

    During the course of metabolism several reactive oxygen species are formed which causes oxidative stress. Plants are the natural source of phytochemicals which can prevent the oxidative stress. Antioxidant property of Leucas aspera was assayed by phosphomolybdate method and was found to be high...

  • EVALUATION OF IN VITRO ANTIOXIDANT POTENTIAL OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS (L.) DIELS. Meena, Mukesh Kumar; Singh, Neelam; Patni, Vidya // International Journal of Pharmacy;2014, Vol. 4 Issue 1, p204 

    Plants are a potential source of natural antioxidants. Antioxidants protect from the potentially damaging oxidative stress, which is a result of an imbalance between the formation of ROS (Reactive oxygen species) and the body antioxidant defense. The present study was directed to investigate the...

  • Endocellular regulation by free radicals and hydrogen peroxide: key determinants of the inflammatory response. Vitetta, Luis; Linnane, Anthony // Inflammopharmacology;Apr2014, Vol. 22 Issue 2, p69 

    The formations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been considered as major contributors to the dysregulation of the inflammatory response. Reactive oxygen species and RNS productions often are reported to be associated with the development of chronic...

  • ROS and RNS in plant physiology: an overview. del Río, Luis A. // Journal of Experimental Botany;May2015 Special Issue, Vol. 66 Issue 10, p2827 

    The production of reactive oxygen species (ROS) is the unavoidable consequence of aerobic life. ROS is a collective term that includes both oxygen radicals, like superoxide (O·2-) and hydroxyl (·OH) radicals, and other non-radicals such as hydrogen peroxide (H2O2), singlet oxygen (1O2 or...

  • Oxidative stress and hepatitis C virus. Paracha, Usman Zafar; Fatima, Kaneez; Alqahtani, Mohammad; Chaudhary, Adeel; Abuzenadah, Adel; Damanhouri, Ghazi; Qadri, Ishtiaq // Virology Journal;2013, Vol. 10 Issue 1, p1 

    The disproportionate imbalance between the systemic manifestation of reactive oxygen species and body's ability to detoxify the reactive intermediates is referred to as oxidative stress. Several biological processes as well as infectious agents, physiological or environmental stress, and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics