TITLE

Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program

AUTHOR(S)
Mitri, J; Nelson, J; Ruthazer, R; Garganta, C; Nathan, D M; Hu, F B; Dawson-Hughes, B; Pittas, A G
PUB. DATE
March 2014
SOURCE
European Journal of Clinical Nutrition;Mar2014, Vol. 68 Issue 3, p376
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background/Objectives:Low blood levels of 25-hydroxyvitamin D (25OHD) have been associated with cardiometabolic disease but results are inconsistent. The objective of the study was to investigate the association of 25OHD with metabolic syndrome in a population at increased risk for diabetes.Subjects/Methods:Using baseline data from the placebo and lifestyle intervention arms of the Diabetes Prevention Program (N=2000), multivariable logistic regression models were used to estimate the odds of prevalent metabolic syndrome and each of its individual components across 25OHD tertiles. Multivariable linear regression was used to estimate the adjusted mean difference of insulin secretion and sensitivity across the same 25OHD tertiles. In participants free of metabolic syndrome at baseline (N=546), incident metabolic syndrome in the first 2 years of follow-up was assessed using discrete-time proportional hazards regression to test its association with 25OHD concentration.Results:After multivariate adjustment, participants in the highest tertile of 25OHD had lower odds of prevalent metabolic syndrome (odds ratio=0.62; 95% confidence interval (CI)=0.45-0.84), smaller waist circumference, higher high-density lipoprotein and lower fasting plasma glucose compared with participants in the lowest tertile of 25OHD. Higher plasma 25OHD concentration was associated with greater insulin sensitivity and lower insulin secretion. After multivariate adjustment, there was a nonsignificant lower risk of metabolic syndrome in the highest tertile of 25OHD (hazard ratio=0.79; 95% CI=0.48-1.32) compared with the lowest tertile.Conclusions:In a population at increased risk for diabetes, higher plasma 25OHD concentration was inversely associated with prevalent metabolic syndrome and nonsignificantly with incident metabolic syndrome.
ACCESSION #
94763012

 

Related Articles

  • Metabolic syndrome and the menopause. Kaaja, Risto J. // Menopause International;Mar2008, Vol. 14 Issue 1, p21 

    The metabolic syndrome consists of a combination of risk factors that include abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance. It increases the risk of cardiovascular disease and type 2 diabetes. The increased risk of cardiovascular disease is higher in women...

  • C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population. Ai-Rong Chen; Hong-Gang Zhang; Zhi-Ping Wang; Sheng-Jun Fu; Pei-Qi Yang; Jian-Gong Ren; Ying-Yuan Ning; Xue-Jian Hu; Ling-Hong Tian // Clinical & Investigative Medicine;Oct2010, Vol. 33 Issue 5, pE290 

    Purpose: Metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are complex diseases affected by both dietary intake and genetic background. Whether N-5, 10- methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, high-sensitivity C-reactive protein (hs-CRP) and dietary...

  • Adiponektyna -- mechanizm dziaÅ‚ania, aktywność biologiczna i nadzieje terapeutyczne. Gola, Mateusz; Grzeszczak, Władysław // Experimental & Clinical Diabetology / Diabetologia Doswiadczalna;2011, Vol. 11 Issue 2, p78 

    Adiponectin is a hormone discovered and described for the first time in 1995. In a number of studies it has been shown that low adiponectin blood concentration is closely associated with the insulin resistance, the metabolic syndrome and with the increased risk of development of type 2 diabetes...

  • The Association Between Vitamin D and Cardiometabolic Risk Factors in Children: A Systematic Review. Dolinsky, Diana H.; Armstrong, Sarah; Mangarelli, Caren; Kemper, Alex R. // Clinical Pediatrics;Mar2013, Vol. 52 Issue 3, p210 

    The objective of this systematic review was to evaluate the association between serum 25-hydroxyvitamin D (25OHD) and cardiometabolic risk in children and the effect of vitamin D supplementation on risk. We included 35 clinical trials, cross-sectional studies, case-control studies, and cohort...

  • Hypertriglyceridemia Is a Practical Biomarker of Metabolic Syndrome in Individuals with Abdominal Obesity. Li, Zhaoping; Deng, Max L.; Tseng, Chi-Hong; Heber, David // Metabolic Syndrome & Related Disorders;Apr2013, Vol. 11 Issue 2, p87 

    Individuals with the metabolic syndrome have a significantly higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Body mass index (BMI) and waist circumference are inaccurate methods for assessing abdominal obesity; in addition, some obese individuals are metabolically...

  • Neck Circumference and Insulin Resistance in Chinese Adults: The Cardiometabolic Risk in Chinese (CRC) Study. JUN LIANG; FEI TENG; YANPING LI; XUEKUI LIU; CAIYAN ZOU; YU WANG; HONGYAN LI; LU QI // Diabetes Care;Sep2013, Vol. 36 Issue 9, pe145 

    A letter to the editor is presented discussing a study on the link of neck circumference to insulin resistance and cardiometabolic risk in Chinese adults.

  • Errata.  // American Journal of Clinical Nutrition;4/1/2017, Vol. 105 Issue 4, p1021 

    A correction is presented to the articles “Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial" and "High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III".

  • The Blood Sugar Solution: The UltraHealthy Program for Losing Weight, Preventing Disease, and Feeling Great Now.  // Life Extension;May2013, Vol. 19 Issue 5, p1 

    A review of the book "The Blood Sugar Solution: The UltraHealthy Program for Losing Weight, Preventing Disease, and Feeling Great Now," by Mark Hyman is presented.

  • AGING & EXERCISE.  // Nutrition Action Health Letter;Jun2011, Vol. 38 Issue 5, p7 

    This article discusses how to reduce the risk of having diabetes in older people through exercise. It shows a link between a decrease in muscle mass and the risk of diabetes. It suggests strength training and aerobic exercise to build muscles. In addition, the article reveals an increase in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics