Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans

Hemminki, K; Musak, L; Vymetalkova, V; Smerhovsky, Z; Halasova, E; Osina, O; Letkova, L; Försti, A; Vodickova, L; Buchancova, J; Vodicka, P
March 2014
Leukemia (08876924);Mar2014, Vol. 28 Issue 3, p721
Academic Journal
The article presents a research study on the translocation of cyclin D1 (CCND1) G870A genotype in multiple myeloma. Odds ratios (ORs) from multivariable linear regression analysis were used to consider impacts of smoking habits. gender and occupational exposures on the frequencies of chromosome-type aberrations (CSAs), chromatid-type aberrations (CTAs) and chromosomal aberrations (CAs). The results for total CAs revealed significant impacts of CCND1 AA genotype and occupational exposure.


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