Elevated PTPN2 expression is associated with inferior molecular response in de-novo chronic myeloid leukaemia patients

Kok, C H; Leclercq, T; Watkins, D B; Saunders, V; Wang, J; Hughes, T P; White, D L
March 2014
Leukemia (08876924);Mar2014, Vol. 28 Issue 3, p702
Academic Journal
The article presents a study on the association of elevated protein tyrosine phosphatase, non-receptor type 2 (PTPN2) expression in patients with chronic myeloid leukemia (CML). The alternative signalling pathways that might activated in the group of high PTPN2 expression related to poor major molecular response (MMR) rates were also investigated. The results suggest that patients having high PTPN2 expression have increased activation of the ß-catenin pathways.


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