On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort

Cortese, D; Sutton, L-A; Cahill, N; Smedby, K E; Geisler, C; Gunnarsson, R; Juliusson, G; Mansouri, L; Rosenquist, R
March 2014
Leukemia (08876924);Mar2014, Vol. 28 Issue 3, p710
Academic Journal
The article presents a multivariate analysis of overall survival (OS) based on the mutational status of SF3B1, NOTCH1, BIRC3 and TP53 genes. The finding shows that the BIRC3 mutation frequency is low at diagnosis, but that mutations might emerge and evolve, specially in patients having relapsing/refractory chronic lymphocytic leukemia (CLL). It reveals that 9.2% of the examined cases harbored big deletions in chromosome 11, which frequently encompassed the whole BIRC3 gene with other genes.


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