Genetic variants and non-genetic factors predict circulating vitamin D levels in Hispanic and non-Hispanic White women: the Breast Cancer Health Disparities Study

Wei Wang; Ingles, Sue Ann; Torres-Mejía, Gabriela; Stern, Mariana C.; Stanczyk, Frank Z.; Schwartz, Gary G.; Nelson, David O.; Fejerman, Laura; Wolff, Roger K.; Slattery, Martha L.; John, Esther M.
January 2014
International Journal of Molecular Epidemiology & Genetics;2014, Vol. 5 Issue 1, p31
Academic Journal
Genome-wide association studies (GWAS) have identified common polymorphisms in or near GC, CYP2R1, CYP24A1, and NADSYN1/DHCR7 genes to be associated with circulating levels of 25-hydroxyvitamin D [25(OH)D] in European populations. To replicate these GWAS findings, we examined six selected polymorphisms from these regions and their relation with circulating 25(OH)D levels in 1,605 Hispanic women (629 U.S. Hispanics and 976 Mexicans) and 354 non-Hispanic White (NHW) women. We also assessed the potential interactions between these variants and known non-genetic predictors of 25(OH)D levels, including body mass index (BMI), sunlight exposure and vitamin D intake from diet and supplements. The minor alleles of the two GC polymorphisms (rs7041 and rs2282679) were significantly associated with lower 25(OH)D levels in both Hispanic and NHW women. The CYP2R1 polymorphism, rs2060793, also was significantly associated with 25(OH)D levels in both groups. We found no significant associations for the polymorphisms in the CYP24A1. In Hispanic controls, 25(OH)D levels were significantly associated with the rs12785878T and rs1790349G haplotype in the NADSYN1/DHCR7 region. Significant interactions between GC rs2282679 and BMI and between rs12785878 and time spent in outdoor activities were observed. These results provide further support for the contribution of common genetic variants to individual variability in circulating 25(OH)D levels. The observed interactions between SNPs and non-genetic factors warrant confirmation.


Related Articles

  • Study of vitamin-D receptor (VDR) gene start codon polymorphism (Fok I) in healthy individuals from North India. Bid, H.K.; Mittal, R.D. // Indian Journal of Human Genetics;Jul-Dec2003, Vol. 9 Issue 2, p51 

    The vitamin D receptor (VDR) gene Fok I polymorphism represents a strong positional candidate susceptibility gene for different diseases like Prostate cancer, Uroilithiasis, Inflammatory bowl disease and Osteoporosis. This genetic variation has also been of great interest due to its possible...

  • Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population. Yi-Cheng Chang; Pi-Hua Liu; Wei-Jei Lee; Tien-Jyun Chang; Yi-Der Jiang; Hung-Yuan Li; Shan-Shan Kuo; Kuang-Chin Lee; Lee-Ming Chuang // Diabetes;Aug2008, Vol. 57 Issue 8, p2245 

    OBJECTIVE--Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS--We...

  • Genome partitioning of genetic variation for complex traits using common SNPs. Jian Yang; Manolio, Teri A.; Pasquale, Louis R.; Boerwinkle, Eric; Caporaso, Neil; Cunningham, Julie M.; de Andrade, Mariza; Feenstra, Bjarke; Feingold, Eleanor; Hayes, M. Geoffrey; Hill, William G.; Landi, Maria Teresa; Alonso, Alvaro; Lettre, Guillaume; Peng Lin; Hua Ling; Lowe, William; Mathias, Rasika A.; Melbye, Mads; Pugh, Elizabeth // Nature Genetics;Jun2011, Vol. 43 Issue 6, p519 

    We estimate and partition genetic variation for height, body mass index (BMI), von Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated individuals. We estimate that ∼45%, ∼17%, ∼25% and ∼21% of the variance in height, BMI, von Willebrand...

  • FTO Variant, Energy Intake, Physical Activity and Basal Metabolic Rate in Caucasians. The HAPIEE Study. HUBÁČEK, J. A.; PIKHART, H.; PEASEY, A.; KUBÍNOVÁ, R.; BOBÁK, M. // Physiological Research;2011, Vol. 60 Issue 1, p175 

    No abstract available.

  • Body Mass Index Change in Females After Short-Time Life Style Intervention Is Not Dependent on the FTO Polymorphisms. DLOUHÁ, D.; SUCHÁNEK, P.; LÁNSKÁ, V.; HUBÁČEK, J. A. // Physiological Research;2011, Vol. 60 Issue 1, p199 

    No abstract available.

  • A polymorphism in the gene encoding AdipoR1 affects olfactory recognition. Guthoff, M.; Tschritter, O.; Berg, D.; Liepelt, I..; Schulte, C.; Machicao, F.; Breer, H.; Haering, H. U.; Fritsche, A. // International Journal of Obesity;Jun2011, Vol. 35 Issue 6, p873 

    Polymorphisms in the gene encoding adiponectin receptor 1 (AdipoR1) are associated with insulin resistance, fatty liver, increased risk for type 2 diabetes and cardiovascular disease. AdipoR1 is expressed in the central nervous system and in the olfactory mucosa of mice and humans. We therefore...

  • SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity. Zillikens, M. Carola; van Meurs, Joyce B. J.; Rivadeneira, Fernando; Amin, Najaf; Hofman, Albert; Oostra, Ben A.; Sijbrands, Eric J. G.; Witteman, Jacqueline C. M.; Pols, Huibert A. P.; van Duijn, Cornelia M.; Uitterlinden, André G. // Diabetes;Dec2009, Vol. 58 Issue 12, p2828 

    OBJECTIVE--SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity. RESEARCH DESIGN AND METHODS--In 6,251 elderly subjects from the prospective, population-based Rotterdam Study, three single nucleotide polymorphisms (SNPs) in the...

  • Genetic Variations in the Serotoninergic System Contribute to Body-Mass Index in Chinese Adolescents. Chen, Chunhui; Chen, Wen; Chen, Chuansheng; Moyzis, Robert; He, Qinghua; Lei, Xuemei; Li, Jin; Wang, Yunxin; Liu, Bin; Xiu, Daiming; Zhu, Bi; Dong, Qi // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Objective: Obesity has become a worldwide health problem in the past decades. Human and animal studies have implicated serotonin in appetite regulation, and behavior genetic studies have shown that body mass index (BMI) has a strong genetic component. However, the roles of genes related to the...

  • Genetic Variation in the NOC Gene Is Associated with Body Mass Index in Chinese Subjects. Chang, Yi-Cheng; Chiu, Yen-Feng; Liu, Pi-Hua; Hee, Siow Wei; Chang, Tien-Jyun; Jiang, Yi-Der; Lee, Wei-Jei; Lee, Po-Chu; Kao, Hui-Yi; Hwang, Juey-Jen; Chuang, Lee-Ming // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    : Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics