TITLE

Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma

AUTHOR(S)
JACOBY, ELAD; YALON, MICHAL; LEITNER, MOSHE; COHEN, ZVI R.; COHEN, YEHUDIT; FISHER, TAMAR; EDER, SARIT; AMARIGLIO, NINETTE; RECHAVI, GIDEON; CAZACU, SIMONA; XIANG, CUNLI; MIKKELSEN, TOM; BRODIE, CHAYA; TOREN, AMOS
PUB. DATE
April 2014
SOURCE
Oncology Letters;2014, Vol. 7 Issue 4, p1209
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization classIV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.
ACCESSION #
94754595

 

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