TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder

April 2014
Oncology Letters;2014, Vol. 7 Issue 4, p1128
Academic Journal
The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and paternally expressed gene (PEG) 10 was assessed in 46 SC/ASCs and 80 adenocarcinomas (ACs) using immunohistochemistry, and the samples were further analyzed to examine correlations with the clinicopathological characteristics. It was demonstrated that positive TSG101 and PEG10 expression were significantly associated with large tumor size, high tumor-node-metastasis (TNM) stage, lymph node metastasis, invasion and no resection (only biopsy) of SC/ASC and AC. The univariate Kaplan-Meier analysis showed that positive TSG101 and PEG10 expression, and differentiation, tumor size, TNM stage, lymph node metastasis, invasion and surgical curability, is closely associated with a decreased overall survival in SC/ASC and AC patients (P<0.05 or P<0.001). The multivariate Cox regression analysis identified that positive TSG101 and PEG10 expression are independent factors for a poor-prognosis in SC/ASC and AC patients. The present study indicates that positive TSG101 and PEG10 expression are closely associated with the clinical, pathological and biological behaviors, and a poor prognosis in gallbladder cancer.


Related Articles

  • Prognostic Value of Lymphangeogenesis and Lymphatic Vessel Invasion in Non-small Cell Lung Cancer. Zhongwu Hu; Wenli Wang; Jie Zhang; Feng Mao; Yang Shen-Tu // Chinese Journal of Lung Cancer;Nov2012, Vol. 15 Issue 11, p656 

    Background and objective: Studies have shown that tumor metastasis in a variety of tumors is associated with lymphangiogenesis and lymphatic vessel invasion (LVI). Tumor metastasis is an important factor that affects the prognosis of patients. The aim of this study is to determine the prognostic...

  • Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer. Peng Chen; Wei-Miao Li; Qiang Lu; Jian Wang; Xiao-Long Yan; Zhi-Pei Zhan; Xiao-Fei Li // BMC Cancer;2014, Vol. 14 Issue 1, p1344 

    Background The expression of novel oncogenic kinase (NOK), a member of the protein tyrosine kinase (PTK) family, has been observed in several human malignancies including non-small cell lung cancer (NSCLC). However, the clinic relevance of NOK expression in NSCLC remains unclear. Methods In this...

  • Expression and Significance of Snail and Claudin-3 in Non-small Cell Lung Cancer. Juan Li; Yuan Tu; Lili Jiang; Huan Xu; Shangfu Zhang // Chinese Journal of Lung Cancer;Oct2012, Vol. 15 Issue 10, p583 

    Background and objective Epithelial-mesenchymal transition (EMT) is considered to be one of the major molecular mechanisms inducing tumor invasion and metastasis. The loss of epithelial cell polarity is a hallmark of the EMT process. Epithelial markers such as Claudin are lost in EMT. Snail is a...

  • Co-expression of receptors of the HER family correlates with clinical outcome in non-small cell lung cancer (NSCLC) Bellezza, Guido; Del Sordo, Rachele; Colella, Renato; Ludovini, Vienna; Ragusa, Mark; Bianconi, Fortunato; Ferri, Ivana; Borri, Filippo; Chiari, Rita; Puma, Francesco; Crinò, Lucio; Sidoni, Angelo // Virchows Archiv;Nov2013, Vol. 463 Issue 5, p663 

    HER family receptors play a critical role in lung carcinogenesis. There is a growing body of evidence showing that cooperation between them contributes to a more aggressive tumor phenotype and impacts on their response to targeted therapy. We explored immunohistochemical co-expression of HER...

  • High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma. Chen, Yan-Feng; Luo, Rong-Zhen; Li, Yong; Cui, Bo-Kang; Song, Ming; Yang, An-Kui; Chen, Wen-Kuan // European Archives of Oto-Rhino-Laryngology;Mar2013, Vol. 270 Issue 3, p1009 

    In order to provide a basis for clinical treatment decisions, we explored whether there was a correlation between the expression of COX-2 and P300 and clinical factors in a group of patients with laryngeal squamous cell carcinoma (LSCC). A retrospective analysis of clinicopathological data was...

  • Clinicopathologic significance and survival of TIP30 expression in laryngeal squamous cell carcinoma. Jianqiu Chen; Chunsheng Zhu; Minhui Zhu; Ming Geng; Yongsheng Tian; Guojun Li; Hongliang Zheng // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 4, p6024 

    Background: The expression and clinical significance of TIP30 and p53 in laryngeal squamous cell carcinoma (LSCC) have not been investigated. Method: We determined immunohistochemically the expression of TIP30 and p53 in surgical specimens from 105 patients with LSCC. Survivals were estimated...

  • Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications. Weihong Zhao; Jiancheng Luo; Shunchang Jiao // Scientific Reports;10/17/2014, p1 

    Long non-coding RNAs (lncRNAs) are a kind of RNAs with regulation that participate fundamental cellular processes via diverse mechanisms. Despite the potential importance of lncRNAs in multiple kinds of cancer has been well studied, no comprehensive survey of cancer subtype associated lncRNAs....

  • INHBA upregulation correlates with poorer prognosis in patients with esophageal squamous cell carcinoma. Lyu, Shanshan; Jiang, Chao; Xu, Rui; Huang, Yuhua; Yan, Shumei // Cancer Management & Research;Jun2018, Vol. 10, p1585 

    Purpose: INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer. However, its clinical significance in esophageal squamous cell carcinoma (ESCC) has never been reported. Patients and methods: In this study,...

  • Outcomes and prognostic factors in gallbladder cancer: a single-centre experience. Cziupka, Katharina; Partecke, Lars; Mirow, Lutz; Heidecke, Claus-Dieter; Emde, Christian; Hoffmann, Wolfgang; Siewert, Ulrike; Berg, Neeltje; Bernstorff, Wolfram; Stier, Albrecht // Langenbeck's Archives of Surgery;Aug2012, Vol. 397 Issue 6, p899 

    Introduction: Gallbladder cancer is the most common malignant tumour of the biliary system with an extraordinarily poor prognosis. In this study, we retrospectively evaluated forty-two patients with histologically proven gallbladder cancer. Patients and methods: Estimated survival rates were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics