TITLE

Pleural fluid prealbumin and C-reactive protein in the differential diagnosis of infectious and malignant pleural effusions

AUTHOR(S)
QIAOYING JI; BIFEI HUANG; MAOFENG WANG; ZHAOXIANG REN; SHA ZHANG; YONGJUN ZHANG; LIJIAN SHENG; YAYAO YU; JINWEN JIANG; DEBAO CHEN; JUN YING; JIONG YU; LIUYI QIU; RUGEN WAN; WEIMIN LI
PUB. DATE
April 2014
SOURCE
Experimental & Therapeutic Medicine;2014, Vol. 7 Issue 4, p778
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Clinical history and physical examination are helpful in indicating the potential causes of pleural effusions (PEs). However, the accurate diagnosis and establishment of the causes of PE is an ongoing challenge in daily clinical practice. The primary aim of this study was to distinguish between infectious PE and malignant PE (MPE) by measuring two major acute phase response biomarkers: prealbumin (PA) and C-reactive protein (CRP). The study was a prospective trial involving 151 patients who were diagnosed with infectious PE or MPE. Patients with infectious PE were divided into two subgroups: tuberculous PE (TBPE) and parapneumonic PE (PNPE). A further 58 patients with PEs that showed no evidence of MPE, TBPE or PNPE were classified as the chronic non-specific PE (NSPE) group. Demographic characteristics and pleural fluids of the subjects were collected consecutively. The discriminative properties of pleural fluid routine biochemistries, and PA and CRP were evaluated. PA, CRP and classical fluid parameters were also applied to classify patients with infectious PE and MPE. Receiver operating
ACCESSION #
94754518

 

Related Articles

  • Calprotectin: a novel biomarker for the diagnosis of pleural effusion. Sánchez-Otero, N; Blanco-Prieto, S; Páez de la Cadena, M; Vázquez-Iglesias, L; Fernández-Villar, A; Botana-Rial, M I; Rodríguez-Berrocal, F J // British Journal of Cancer;11/20/2012, Vol. 107 Issue 11, p1876 

    Background:Novel non-invasive biomarkers for the precise diagnosis of malignancy in pleural effusion (PE) are needed. The aim of this study was to determine the diagnostic accuracy of calprotectin for predicting malignancy in patients with exudative PE.Methods:Calprotectin concentration was...

  • Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population. Allin, K H; Bojesen, S E; Johansen, J S; Nordestgaard, B G // British Journal of Cancer;1/3/2012, Vol. 106 Issue 1, p199 

    Background:YKL-40 and C-reactive protein (CRP) are biomarkers that may reflect cancer-related subclinical inflammation. We assessed elevated YKL-40 and CRP levels as combined risk predictors for cancer.Methods:We measured plasma YKL-40 and CRP at baseline in 8706 individuals from the Danish...

  • Interleukin 27 Could Be Useful in the Diagnosis of Tuberculous Pleural Effusions. Valdės, Luis; San Josė, Esther; Ferreiro, Lucía; Golpe, Antonio; Gude, Francisco; Álvarez-Dobaño, Josė M.; Pereyra, Marco F.; Toubes, María E.; González-Barcala, Francisco J. // Respiratory Care;Mar2014, Vol. 59 Issue 3, p399 

    BACKGROUND: The diagnosis of tuberculous pleural effusion (TBPE) has some limitations. We studied the efficacy of interleukin-27 (IL-27) in the diagnosis of TBPE. METHODS: We measured IL-27, adenosine deaminase (ADA), ADA-2, interferon-gamma (IFN), and the ADAIL-27 and ADA-2IL-27 products in all...

  • Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. I Olaciregui // Archives of Disease in Childhood;Jul2009, Vol. 94 Issue 7, p501 

    OBJECTIVE: To evaluate potential markers of serious bacterial infection (SBI) in infants under 3 months of age presenting with fever of unknown origin. MATERIAL AND METHODS: We retrospectively studied all infants under 3 months of age seen in the emergency department between January 2004 and...

  • The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer. Khan, aftab a.; akritidis, Georgios; Pring, Toby; alagarathnam, Swethan; Roberts, Geoffrey; Raymond, Regina; Varcada, Massimo; Novell, Richard // Oncology;Aug2016, Vol. 91 Issue 2, p69 

    Aim: The aim of the study was to investigate the role of the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of rectal cancers. Methods: We undertook a retrospective review of patients with rectal cancer. Pre-treatment NLR was assessed for association and predictive values against...

  • Pleural Fluid Amino-Terminal Brain Natriuretic Peptide in Patients With Pleural Effusions. Cincin, Altug; Abul, Yasin; Ozben, Beste; Tanrikulu, Azra; Topaloglu, Nurhayat; Ozgul, Gulsevil; Karakurt, Sait; Oktay, Ahmet // Respiratory Care;Feb2013, Vol. 58 Issue 2, p313 

    BACKGROUND: Definite diagnosis of transudative or exudative pleural fluids often presents a diagnostic dilemma. The aim of this study was to evaluate whether amino-terminal brain natriuretic peptide (NT-proBNP) levels in pleural fluid has a diagnostic value for discriminating heart-failure...

  • C-Reactive Protein Predicts Pleurodesis Success in Malignant Pleural Effusion Patients. Lapidot, Moshe; Faber, Dan Levy; Nir, Rony-Reuven; Orlovsky, Michael; Kagan, Michael; Best, Lael Anson; Kremer, Ran // Journal of Palliative Medicine;Apr2013, Vol. 16 Issue 4, p337 

    A letter to the editor is presented which presents a study to examine the goals of management for malignant pleural effusions (MPE). It was evaluated if the the C-reactive protein (CRP) levels in the intrapleural fluid would predict the clinical improvement in the patient's condition. The study...

  • Endocan—A Novel Inflammatory Indicator in Newly Diagnosed Patients With Hypertension: A Pilot Study. Balta, Sevket; Mikhailidis, Dimitri P.; Demirkol, Sait; Ozturk, Cengiz; Kurtoglu, Ertugrul; Demir, Mustafa; Celik, Turgay; Turker, Turker; Iyisoy, Atila // Angiology;Oct2014, Vol. 65 Issue 9, p773 

    Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell–specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we...

  • Maternal serum interleukin 6 and 8 and C-reactive protein in predicting the tocolytic therapy in preterm labor. Shahshahan, Zahra; Hashemi, Leila; Rasouli, Ousha // Journal of Research in Medical Sciences;Jun2014, Vol. 19 Issue 6, p537 

    Background: This study aimed to evaluate the relation between C-reactive protein (CRP), interleukin (IL) 6 and 8 with the response to tocolytic therapy. Materials and Methods: A total of 75 singleton pregnant women between 18 and 35 years old, and with symptoms of preterm labor were hospitalized...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics