Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for rectal cancer: a case report

Masahiro Manabe; Takafumi Nishii; Junya Okita; Johji Nagasaki; Naonori Harada; Yasutaka Aoyama; Takeo Kumura; Tadanobu Ohta; Yoshio Furukawa; Kazuhiro Takeuchi; Atsuko Mugitani
October 2013
American Journal of Blood Research;2013, Vol. 3 Issue 4, p286
Academic Journal
We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Although it remains unclear that CML that develops after treatment involving cytotoxic agents is treatment-related, clinicians should be aware of the possibility of CML developing after S-1 therapy.


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