To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis

Schirmer, Lucas; Srivastava, Rajneesh; Hemmer, Bernhard
March 2014
Multiple Sclerosis Journal;Mar2014, Vol. 20 Issue 3, p271
Academic Journal
The search for autoantibodies in multiple sclerosis (MS) has been challenging for the last 3 decades. With the development of new proteomic methods and advances in expression and assay technologies, progress in the identification of MS autoantibodies has been made. A number of MS-specific autoantibodies have been proposed, most of them targeting proteins expressed in oligodendrocytes and along the myelin sheath. In this review, we summarize the status of antibody research in MS and then discuss recent developments and future strategies in defining and characterizing the potential antigenic targets of autoantibodies in MS.


Related Articles

  • The Lesions of Multiple Sclerosis. Paty, Donald W.; Arnold, Douglas L. // New England Journal of Medicine;1/17/2002, Vol. 346 Issue 3, p199 

    Editorial. Discusses multiple sclerosis (MS). Reference to reports by Chang and colleagues and by Brex et al in this issue; How the findings are important to an understanding of the remyelination of lesions of MS and imply that transplantation of oligodendrocyte precursor cells will probably not...

  • Analysis of the direct injury effector of oligodendroglia cells or myelin sheath in an experimental allergic encephalomyelitis model induced by the MOG35-55 peptide. XIANGYU ZHOU; XIAOYONG LI; MEINA FENG; QI ZHANG; ZHENDONG YANG // Molecular Medicine Reports;2015, Vol. 12 Issue 5, p7425 

    The aim of the present study was to investigate the possible role of cytotoxic T lymphocytes (CTL) and mononuclear macrophages in the pathogenic processes of experimental animals. To construct a chronic experimental allergic encephalomyelitis (EAE) model, an artificially synthesized myelin...

  • Interaction of PLP with GFP-MAL2 in the Human Oligodendroglial Cell Line HOG. Bello-Morales, Raquel; Pérez-Hernández, Marta; Rejas, María Teresa; Matesanz, Fuencisla; Alcina, Antonio; López-Guerrero, José Antonio // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing...

  • Identification of autoantibodies associated with myelin damage in multiple sclerosis. Genain, Claude P.; Cannella, Barbara; Hauser, Stephen L.; Raine, Cedric S. // Nature Medicine;Feb1999, Vol. 5 Issue 2, p170 

    The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin antigens and high-resolution microscopy, techniques that can detect antigen-specific antibodies in situ, we have identified autoantibodies...

  • Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis. Chang, Ansi; Tourtellotte, Wallace W.; Rudick, Richard; Trapp, Bruce D. // New England Journal of Medicine;1/17/2002, Vol. 346 Issue 3, p165 

    Background: Multiple sclerosis is an inflammatory disease of the central nervous system that destroys myelin, oligodendrocytes, and axons. Since most of the lesions of multiple sclerosis are not remyelinated, enhancement of remyelination is a possible therapeutic strategy that could perhaps be...

  • Mechanisms Underlying the Process of Demyelination in Multiple Sclerosis.  // Neurophysiology;Oct2009, Vol. 41 Issue 5, p365 

    The author analyzes published data and her own findings related to the cellular and molecular mechanisms underlying a demyelinating disease multiple sclerosis. She discussed the mechanisms of the immunopathogenic process in multiple sclerosis, the involvement of microglia and astrocytes in...

  • MULTIPLE SCLEROSIS AND HUMAN ENHANCEMENT. de Wolf, Chana // Cryonics;Feb2014, Vol. 35 Issue 2, p6 

    The article offers a perspective on multiple sclerosis (MS) in relation to the biogerontology, cryonics, and immune improvements for biological human enhancements. It describes MS as a inflammatory disorder of central nervous system resulting in axonal degeneration in the brain and in the spinal...

  • Receiving mixed signals: uncoupling oligodendrocyte differentiation and myelination. Rosenberg, S. S.; Powell, B. L.; Chan, J. R. // Cellular & Molecular Life Sciences;Dec2007, Vol. 64 Issue 23, p3059 

    The development and maturation of an oligodendroglial cell is comprised of three intimately related processes that include proliferation, differentiation, and myelination. Here we review how proliferation and differentiation are controlled by distinct molecular mechanisms and discuss whether...

  • Lysophosphatidic Acid can Support the Formation of Membranous Structures and an Increase in MBP mRNA Levels in Differentiating Oligodendrocytes. Larra Yuelling; Jameel Dennis; Karen Gorse; Shawn Payne; Babette Fuss // Neurochemical Research;Jan2009, Vol. 34 Issue 1, p182 

    Abstract  During development, differentiating oligodendrocytes progress in distinct maturation steps from premyelinating to myelinating cells. Such maturing oligodendrocytes express both the receptors mediating signaling via extracellular lysophosphatidic acid (LPA) and the major enzyme...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics