TITLE

To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis

AUTHOR(S)
Schirmer, Lucas; Srivastava, Rajneesh; Hemmer, Bernhard
PUB. DATE
March 2014
SOURCE
Multiple Sclerosis Journal;Mar2014, Vol. 20 Issue 3, p271
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The search for autoantibodies in multiple sclerosis (MS) has been challenging for the last 3 decades. With the development of new proteomic methods and advances in expression and assay technologies, progress in the identification of MS autoantibodies has been made. A number of MS-specific autoantibodies have been proposed, most of them targeting proteins expressed in oligodendrocytes and along the myelin sheath. In this review, we summarize the status of antibody research in MS and then discuss recent developments and future strategies in defining and characterizing the potential antigenic targets of autoantibodies in MS.
ACCESSION #
94744222

 

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