TITLE

Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration

AUTHOR(S)
Rossi, Silvia; Motta, Caterina; Studer, Valeria; Barbieri, Francesca; Buttari, Fabio; Bergami, Alessandra; Sancesario, Giulia; Bernardini, Sergio; De Angelis, Gottardo; Martino, Gianvito; Furlan, Roberto; Centonze, Diego
PUB. DATE
March 2014
SOURCE
Multiple Sclerosis Journal;Mar2014, Vol. 20 Issue 3, p304
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which investigates the synaptic mechanism of inflammatory neurodegeneration in progressive multiple sclerosis (MS). Details about the methods of the study are provided. An observation of an increased spontaneous excitatory postsynaptic currents, along with the pathogenic role of B cells in tumor necrosis factor (TNF) cerebrospinal fluid increase, is discussed. The study suggests TNF as a major neurotoxic molecule in progressive MS.
ACCESSION #
94744214

 

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